A phase III randomized study comparing oral doxifluridine and oral 5-fluorouracil after curative resection of gastric cancer.

  • Authors:
    • N Takiguchi
    • N Nakajima
    • N Saitoh
    • S Fujimoto
    • H Nakazato
  • View Affiliations

  • Published online on: May 1, 2000     https://doi.org/10.3892/ijo.16.5.1021
  • Pages: 1021-1028
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Abstract

To investigate the usefulness of oral doxifluridine (5'-DFUR), an active intermediate metabolite of capecitabine (XELODA), in gastric cancer patients after curative resection, we conducted a phase III randomized controlled study to compare oral 5'-DFUR and oral 5-fluorouracil (5-FU). 485 gastric cancer patients with Stage II or III operative findings at curative resection were registered and administered 5'-DFUR (460 mg/m2/day, daily, for two years) or 5-FU (115 mg/m2/day, daily, for the same period). Although no differences in overall survival or disease-free survival were detected, subset analysis showed 5'-DFUR was more effective in reducing peritoneal recurrence than 5-FU (p = 0.047), and in patients with Stage III or stage IIIb (histologic findings) in the 5'-DFUR group had more favorable disease-free survival curves and survival curves than the 5-FU group with similar stages.

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May 2000
Volume 16 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Takiguchi, N., Nakajima, N., Saitoh, N., Fujimoto, S., & Nakazato, H. (2000). A phase III randomized study comparing oral doxifluridine and oral 5-fluorouracil after curative resection of gastric cancer.. International Journal of Oncology, 16, 1021-1028. https://doi.org/10.3892/ijo.16.5.1021
MLA
Takiguchi, N., Nakajima, N., Saitoh, N., Fujimoto, S., Nakazato, H."A phase III randomized study comparing oral doxifluridine and oral 5-fluorouracil after curative resection of gastric cancer.". International Journal of Oncology 16.5 (2000): 1021-1028.
Chicago
Takiguchi, N., Nakajima, N., Saitoh, N., Fujimoto, S., Nakazato, H."A phase III randomized study comparing oral doxifluridine and oral 5-fluorouracil after curative resection of gastric cancer.". International Journal of Oncology 16, no. 5 (2000): 1021-1028. https://doi.org/10.3892/ijo.16.5.1021