Increased expression of NIPP-1 mRNA correlates positively with malignant phenotype in rat hepatomas.

  • Authors:
    • S E Kim
    • A Ishita
    • H Shima
    • K Nakamura
    • Y Yamada
    • K Ogawa
    • K Kikuchi
  • View Affiliations

  • Published online on: April 1, 2000     https://doi.org/10.3892/ijo.16.4.751
  • Pages: 751-756
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Abstract

In order to elucidate an involvement of protein phosphatase type 1 (PP1) in the malignant transformation, we have isolated rat cDNA for NIPP-1, a nuclear inhibitor for PP1. Rat NIPP-1 protein conserved the PP1 binding domain and the nuclear targeting sequence. The mRNA was ubiquitously expressed with the highest expression in bone marrow and thymus. The rat NIPP1 mRNA levels were slightly, if at all, increased in some primary hepatomas, and significantly increased in rat ascites hepatomas. The levels of NIPP-1 mRNA were closely correlated with malignant phenotype of rat ascites hepatomas, suggesting that NIPP-1 is tightly linked to malignant phenotype in hepatomas.

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April 2000
Volume 16 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Kim, S., Ishita, A., Shima, H., Nakamura, K., Yamada, Y., Ogawa, K., & Kikuchi, K. (2000). Increased expression of NIPP-1 mRNA correlates positively with malignant phenotype in rat hepatomas.. International Journal of Oncology, 16, 751-756. https://doi.org/10.3892/ijo.16.4.751
MLA
Kim, S., Ishita, A., Shima, H., Nakamura, K., Yamada, Y., Ogawa, K., Kikuchi, K."Increased expression of NIPP-1 mRNA correlates positively with malignant phenotype in rat hepatomas.". International Journal of Oncology 16.4 (2000): 751-756.
Chicago
Kim, S., Ishita, A., Shima, H., Nakamura, K., Yamada, Y., Ogawa, K., Kikuchi, K."Increased expression of NIPP-1 mRNA correlates positively with malignant phenotype in rat hepatomas.". International Journal of Oncology 16, no. 4 (2000): 751-756. https://doi.org/10.3892/ijo.16.4.751