The effect of p53-function on the sensitivity to paclitaxel with or without hyperthermia in human colorectal carcinoma cells.

  • Authors:
    • C van Bree
    • J H Savonije
    • N A Franken
    • J Haveman
    • P J Bakker
  • View Affiliations

  • Published online on: April 1, 2000     https://doi.org/10.3892/ijo.16.4.739
  • Pages: 739-783
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Abstract

The importance of p53-function for the sensitivity to paclitaxel with and without hyperthermia (HT) was studied in an isogenic cell line system. The inactivation of p53 decreased sensitivity to paclitaxel (1.1-2.5-fold), which correlated with a lower induction of apoptosis. The magnitude of the G2/M arrest after treatment with paclitaxel was similar in all cell lines. The cytotoxicity of paclitaxel was not enhanced by HT in either wild-type p53 or p53-inactivated cells. In conclusion, cellular sensitivity to paclitaxel depends on p53-function by its ability to induce apoptosis. Irrespective of the p53-function HT was not able to enhance the sensitivity to paclitaxel.

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April 2000
Volume 16 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
van Bree, C., Savonije, J., Franken, N., Haveman, J., & Bakker, P. (2000). The effect of p53-function on the sensitivity to paclitaxel with or without hyperthermia in human colorectal carcinoma cells.. International Journal of Oncology, 16, 739-783. https://doi.org/10.3892/ijo.16.4.739
MLA
van Bree, C., Savonije, J., Franken, N., Haveman, J., Bakker, P."The effect of p53-function on the sensitivity to paclitaxel with or without hyperthermia in human colorectal carcinoma cells.". International Journal of Oncology 16.4 (2000): 739-783.
Chicago
van Bree, C., Savonije, J., Franken, N., Haveman, J., Bakker, P."The effect of p53-function on the sensitivity to paclitaxel with or without hyperthermia in human colorectal carcinoma cells.". International Journal of Oncology 16, no. 4 (2000): 739-783. https://doi.org/10.3892/ijo.16.4.739