Enhancement of the transformed shape phenotype by microtubule inhibitors and reversal by an inhibitor combination.
- C A Heckman
- H K Plummer
- R Mukherjee
Affiliations: Department of Biological Sciences, Bowling Green State University, Bowling Green, OH 43403-0212, USA.
- Published online on: April 1, 2000 https://doi.org/10.3892/ijo.16.4.709
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Differences between transformed cells and their normal counterparts were defined by analyzing the cells' three-dimensional distribution of mass. Variables called factors, which explained the covariance of the real variables, were extracted from the data. We found that factors #4 (sharp, tapering projections) and #12 (rounding up), corresponded to G-protein functions. Then, the signature-type mass distribution of transformed cells was defined by factor values. Agents that caused signature-type mimicry could quantitatively shift factor values, for example, those affecting endocytic processing disproportionately reduced values of #4. Signature-type reversal was also observed and may be valuable in predicting the efficacy of chemotherapeutic agents.