Translocation and coamplification of loci from chromosome arms 8p and 11q in the MDA-MB-175 mammary carcinoma cell line.

  • Authors:
    • J Adélaïde
    • M Chaffanet
    • M J Mozziconacci
    • C Popovici
    • N Conte
    • F Fernandez
    • H Sobol
    • J Jacquemier
    • M Pébusque
    • D Ron
    • M Lafage-Pochitaloff
    • D Birnbaum
  • View Affiliations

  • Published online on: April 1, 2000     https://doi.org/10.3892/ijo.16.4.683
  • Pages: 683-691
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Abstract

Rearrangement and coamplification of the 8p12 and 11q13 chromosomal regions occurs in a significant proportion of breast cancers. It usually involves a complex hybrid structure in which the FGFR1 and CCND1 genes are amplified. We report here a different type of 8p12-11q13 rearrangement in the MDA-MB-175 mammary carcinoma cell line. This amplification contains the NRG1/HGL (from 8p12-21) and DOC4 (from 11q13) genes, encoding respectively a ligand for ERBB receptors and a stress-induced protein which is a mammalian ortholog of Drosophila Tenm/Odz. It has been shown previously (Wang et al, Oncogene 18: 5718-5721, 1999) that these two genes are rearranged and fused by a translocation event. This type of event was not found in 30 tumors tested that showed coamplification of the 8p12 and 11q13 regions.

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April 2000
Volume 16 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Adélaïde, J., Chaffanet, M., Mozziconacci, M., Popovici, C., Conte, N., Fernandez, F. ... Birnbaum, D. (2000). Translocation and coamplification of loci from chromosome arms 8p and 11q in the MDA-MB-175 mammary carcinoma cell line.. International Journal of Oncology, 16, 683-691. https://doi.org/10.3892/ijo.16.4.683
MLA
Adélaïde, J., Chaffanet, M., Mozziconacci, M., Popovici, C., Conte, N., Fernandez, F., Sobol, H., Jacquemier, J., Pébusque, M., Ron, D., Lafage-Pochitaloff, M., Birnbaum, D."Translocation and coamplification of loci from chromosome arms 8p and 11q in the MDA-MB-175 mammary carcinoma cell line.". International Journal of Oncology 16.4 (2000): 683-691.
Chicago
Adélaïde, J., Chaffanet, M., Mozziconacci, M., Popovici, C., Conte, N., Fernandez, F., Sobol, H., Jacquemier, J., Pébusque, M., Ron, D., Lafage-Pochitaloff, M., Birnbaum, D."Translocation and coamplification of loci from chromosome arms 8p and 11q in the MDA-MB-175 mammary carcinoma cell line.". International Journal of Oncology 16, no. 4 (2000): 683-691. https://doi.org/10.3892/ijo.16.4.683