Expression and mutation patterns of p53 in benign and malignant salivary gland tumors.

  • Authors:
    • A Nordkvist
    • E Röijer
    • G Bang
    • H Gustafsson
    • M Behrendt
    • W Ryd
    • S Thoresen
    • K Donath
    • G Stenman
  • View Affiliations

  • Published online on: March 1, 2000     https://doi.org/10.3892/ijo.16.3.477
  • Pages: 477-560
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Abstract

The expression and mutation patterns of p53 were studied in a series of 68 benign pleomorphic adenomas and 237 malignant salivary gland tumors. p53 overexpression (nuclear staining exceeding 10%) was detected in 20% of the malignant salivary gland tumors, with the highest prevalence observed in polymorphous low grade adenocarcinoma, squamous cell carcinoma, and carcinoma ex pleomorphic adenoma and the lowest in adenoid cystic carcinoma and acinic cell carcinoma. In contrast, none of the 68 benign pleomorphic adenomas had nuclear staining exceeding 10%. SSCP and nucleotide sequence analysis of exons 4 to 9 of p53 in 19 malignant tumors revealed 9 mutations in 7 tumors. Our findings indicate that p53 may be a useful marker to help discriminate between benign and malignant salivary gland tumors.

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March 2000
Volume 16 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Nordkvist, A., Röijer, E., Bang, G., Gustafsson, H., Behrendt, M., Ryd, W. ... Stenman, G. (2000). Expression and mutation patterns of p53 in benign and malignant salivary gland tumors.. International Journal of Oncology, 16, 477-560. https://doi.org/10.3892/ijo.16.3.477
MLA
Nordkvist, A., Röijer, E., Bang, G., Gustafsson, H., Behrendt, M., Ryd, W., Thoresen, S., Donath, K., Stenman, G."Expression and mutation patterns of p53 in benign and malignant salivary gland tumors.". International Journal of Oncology 16.3 (2000): 477-560.
Chicago
Nordkvist, A., Röijer, E., Bang, G., Gustafsson, H., Behrendt, M., Ryd, W., Thoresen, S., Donath, K., Stenman, G."Expression and mutation patterns of p53 in benign and malignant salivary gland tumors.". International Journal of Oncology 16, no. 3 (2000): 477-560. https://doi.org/10.3892/ijo.16.3.477