DLX-7 homeobox gene regulates c-myc and GATA-1 gene expression in different stages respectively.

  • Authors:
    • T Shimamoto
    • K Ohyashiki
    • K Takeshita
  • View Affiliations

  • Published online on: August 1, 1999     https://doi.org/10.3892/ijo.15.2.307
  • Pages: 307-320
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Abstract

Homeobox genes code for transcription factors with a highly conserved DNA binding motif, but their target genes are largely unknown. We have shown that inhibition of the DLX-7 homeobox gene by an antisense oligonucleotide decreased the expression of c-myc and GATA-1 genes. Nuclear run-on assay revealed decreased transcriptional activity of c-myc but not of GATA-1 after DLX-7 antisense treatment. Actinomycin D chase experiments demonstrated that GATA-1 mRNA became unstable as a result of DLX-7 inhibition, whereas c-myc mRNA stability was unaffected. These results suggest that DLX-7 may regulate c-myc and GATA-1 genes at transcriptional and post-transcriptional levels.

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August 1999
Volume 15 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Shimamoto, T., Ohyashiki, K., & Takeshita, K. (1999). DLX-7 homeobox gene regulates c-myc and GATA-1 gene expression in different stages respectively.. International Journal of Oncology, 15, 307-320. https://doi.org/10.3892/ijo.15.2.307
MLA
Shimamoto, T., Ohyashiki, K., Takeshita, K."DLX-7 homeobox gene regulates c-myc and GATA-1 gene expression in different stages respectively.". International Journal of Oncology 15.2 (1999): 307-320.
Chicago
Shimamoto, T., Ohyashiki, K., Takeshita, K."DLX-7 homeobox gene regulates c-myc and GATA-1 gene expression in different stages respectively.". International Journal of Oncology 15, no. 2 (1999): 307-320. https://doi.org/10.3892/ijo.15.2.307