Comparative genomic hybridization defines frequent loss on 16p in human anaplastic thyroid carcinoma.

  • Authors:
    • Y Komoike
    • Y Tamaki
    • I Sakita
    • N Tomita
    • M Ohue
    • M Sekimoto
    • M Miyazaki
    • M Kadota
    • N Masuda
    • M Ooka
    • T Ohnishi
    • Y Nakano
    • T Kozaki
    • T Kobayashi
    • N Matsuura
    • T Ikeda
    • A Horii
    • M Monden
  • View Affiliations

  • Published online on: June 1, 1999     https://doi.org/10.3892/ijo.14.6.1157
  • Pages: 1157-1219
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Abstract

Anaplastic thyroid cancer (ATC) is one of the malignant tumors with the poor prognosis that is thought to arise from well-differentiated thyroid cancer (DTC). To investigate the molecular mechanism of ATC, we studied genomic alterations of eight ATC cell lines and three DTC cell lines by means of the comparative genomic hybridization (CGH) method. Loss of 16p was observed in five of eight ATC cell lines (62. 5%), but none of the three DTC cell lines showed loss of this chromosome arm. It is notable that loss of 18q [7/8 of ATC (87.5%), 2/3 of DTC (67%)] and gain of 20q [5/8 of ATC (62.5%), 3/3 of DTC (100%)] were frequently seen in both histologic types. Our results suggest that there is a gene in 16p that is closely associated with transformation from well-differentiated thyroid cancer to anaplastic cancer.

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Jun 1999
Volume 14 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Komoike, Y., Tamaki, Y., Sakita, I., Tomita, N., Ohue, M., Sekimoto, M. ... Monden, M. (1999). Comparative genomic hybridization defines frequent loss on 16p in human anaplastic thyroid carcinoma.. International Journal of Oncology, 14, 1157-1219. https://doi.org/10.3892/ijo.14.6.1157
MLA
Komoike, Y., Tamaki, Y., Sakita, I., Tomita, N., Ohue, M., Sekimoto, M., Miyazaki, M., Kadota, M., Masuda, N., Ooka, M., Ohnishi, T., Nakano, Y., Kozaki, T., Kobayashi, T., Matsuura, N., Ikeda, T., Horii, A., Monden, M."Comparative genomic hybridization defines frequent loss on 16p in human anaplastic thyroid carcinoma.". International Journal of Oncology 14.6 (1999): 1157-1219.
Chicago
Komoike, Y., Tamaki, Y., Sakita, I., Tomita, N., Ohue, M., Sekimoto, M., Miyazaki, M., Kadota, M., Masuda, N., Ooka, M., Ohnishi, T., Nakano, Y., Kozaki, T., Kobayashi, T., Matsuura, N., Ikeda, T., Horii, A., Monden, M."Comparative genomic hybridization defines frequent loss on 16p in human anaplastic thyroid carcinoma.". International Journal of Oncology 14, no. 6 (1999): 1157-1219. https://doi.org/10.3892/ijo.14.6.1157