Detection of hepatitis B virus X-region DNA in liver tissue from patients with hepatitis C virus-associated cirrhosis who subsequently developed hepatocellular carcinoma.

  • Authors:
    • Y Shibata
    • K Nakata
    • S Tsuruta
    • K Hamasaki
    • Y Hayashida
    • Y Kato
    • K Nakao
    • K Eguchi
  • View Affiliations

  • Published online on: June 1, 1999     https://doi.org/10.3892/ijo.14.6.1153
  • Pages: 1153-1159
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The risk of hepatocellular carcinoma (HCC) in patients chronically infected by hepatitis C virus (HCV) is relatively higher in Japan than in Western countries. The presence of hepatitis B virus X (HBX)-DNA in the liver tissue samples obtained on enrollment from 69 patients with HCV-associated cirrhosis who were subsequently followed in our hospital was analyzed by polymerase chain reaction (PCR). During the follow-up period of 5.7+/-3.2 years (mean +/- SD), 52 (75%) of 69 patients developed HCC. The PCR analysis indicated that the HBX-DNA sequence was detected in 25 (48%) of 52 patients who developed HCC during follow-up, but in only 3 (18%) of 17 patients who did not (P<0.05). These results suggest that HBX, a hepatitis B viral product relevant to hepatocarcinogenesis, is involved in development of HCC in some patients chronically infected by HCV in Japan.

Related Articles

Journal Cover

Jun 1999
Volume 14 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Shibata, Y., Nakata, K., Tsuruta, S., Hamasaki, K., Hayashida, Y., Kato, Y. ... Eguchi, K. (1999). Detection of hepatitis B virus X-region DNA in liver tissue from patients with hepatitis C virus-associated cirrhosis who subsequently developed hepatocellular carcinoma.. International Journal of Oncology, 14, 1153-1159. https://doi.org/10.3892/ijo.14.6.1153
MLA
Shibata, Y., Nakata, K., Tsuruta, S., Hamasaki, K., Hayashida, Y., Kato, Y., Nakao, K., Eguchi, K."Detection of hepatitis B virus X-region DNA in liver tissue from patients with hepatitis C virus-associated cirrhosis who subsequently developed hepatocellular carcinoma.". International Journal of Oncology 14.6 (1999): 1153-1159.
Chicago
Shibata, Y., Nakata, K., Tsuruta, S., Hamasaki, K., Hayashida, Y., Kato, Y., Nakao, K., Eguchi, K."Detection of hepatitis B virus X-region DNA in liver tissue from patients with hepatitis C virus-associated cirrhosis who subsequently developed hepatocellular carcinoma.". International Journal of Oncology 14, no. 6 (1999): 1153-1159. https://doi.org/10.3892/ijo.14.6.1153