Cholecystokinin regulates the invasiveness of human pancreatic cancer cell lines via protein kinase C pathway.

  • Authors:
    • M Hirata
    • A Tsuchida
    • T Iwao
    • T Sasaki
    • K Matsubara
    • S Yamamoto
    • K Morinaka
    • Y Kawasaki
    • Y Fujimoto
    • H Inoue
    • K Kariya
    • G Kajiyama
  • View Affiliations

  • Published online on: June 1, 1999     https://doi.org/10.3892/ijo.14.6.1129
  • Pages: 1129-1164
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Abstract

We have previously reported that cholecystokinin (CCK) plays an important role in the invasiveness and the production of matrix metalloproteinase-9 (MMP-9) in two human pancreatic cancer cell lines. In this study we investigated the pathway of the invasiveness associated with MMP-9 of those lines regulated by CCK. Two human pancreatic cancer cell lines were treated with CCK-8 alone, CCK-8 and staurosporine, or CCK-8 and indomethacine. The invasiveness and the production of MMP-9 were decreased with staurosporine but not indomethacine. These results suggest that CCK may regulate the invasiveness and the production of MMP-9 via protein kinase C in human pancreatic cancer cell lines.

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Jun 1999
Volume 14 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Hirata, M., Tsuchida, A., Iwao, T., Sasaki, T., Matsubara, K., Yamamoto, S. ... Kajiyama, G. (1999). Cholecystokinin regulates the invasiveness of human pancreatic cancer cell lines via protein kinase C pathway.. International Journal of Oncology, 14, 1129-1164. https://doi.org/10.3892/ijo.14.6.1129
MLA
Hirata, M., Tsuchida, A., Iwao, T., Sasaki, T., Matsubara, K., Yamamoto, S., Morinaka, K., Kawasaki, Y., Fujimoto, Y., Inoue, H., Kariya, K., Kajiyama, G."Cholecystokinin regulates the invasiveness of human pancreatic cancer cell lines via protein kinase C pathway.". International Journal of Oncology 14.6 (1999): 1129-1164.
Chicago
Hirata, M., Tsuchida, A., Iwao, T., Sasaki, T., Matsubara, K., Yamamoto, S., Morinaka, K., Kawasaki, Y., Fujimoto, Y., Inoue, H., Kariya, K., Kajiyama, G."Cholecystokinin regulates the invasiveness of human pancreatic cancer cell lines via protein kinase C pathway.". International Journal of Oncology 14, no. 6 (1999): 1129-1164. https://doi.org/10.3892/ijo.14.6.1129