Analysis of cyclin dependent kinase inhibitors in malignant astrocytomas.

  • Authors:
    • C H Alleyne
    • J He
    • J Yang
    • S B Hunter
    • G Cotsonis
    • C D James
    • J J Olson
  • View Affiliations

  • Published online on: June 1, 1999     https://doi.org/10.3892/ijo.14.6.1111
  • Pages: 1111-1117
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Abstract

The cyclin-dependent kinase inhibitors p16, p21, and p27 in human brain, and brain tumors were examined to explore clinicopathologic correlations. Western analysis and immunohistochemistry was performed and correlated retrospectively with the patients clinical characteristics. A trend was found between increased progression-free survival and p27 expression. There was no correlation between p27 expression and age or gender. The expression of p27 in malignant gliomas may have prognostic value. In addition, an investigation of the therapeutic benefit of overexpression of this cyclin-dependent kinase inhibitor is warranted given reports of diminished malignant potential of tumors expressing p27.

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Jun 1999
Volume 14 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Alleyne, C., He, J., Yang, J., Hunter, S., Cotsonis, G., James, C., & Olson, J. (1999). Analysis of cyclin dependent kinase inhibitors in malignant astrocytomas.. International Journal of Oncology, 14, 1111-1117. https://doi.org/10.3892/ijo.14.6.1111
MLA
Alleyne, C., He, J., Yang, J., Hunter, S., Cotsonis, G., James, C., Olson, J."Analysis of cyclin dependent kinase inhibitors in malignant astrocytomas.". International Journal of Oncology 14.6 (1999): 1111-1117.
Chicago
Alleyne, C., He, J., Yang, J., Hunter, S., Cotsonis, G., James, C., Olson, J."Analysis of cyclin dependent kinase inhibitors in malignant astrocytomas.". International Journal of Oncology 14, no. 6 (1999): 1111-1117. https://doi.org/10.3892/ijo.14.6.1111