Expression of wild-type p53 gene confers increased sensitivity to radiation and chemotherapeutic agents in human esophageal carcinoma cells.

  • Authors:
    • H Matsubara
    • M Kimura
    • M Sugaya
    • Y Koide
    • Y Gunji
    • K Takegana
    • T Asano
    • T Ochiai
    • K Isono
    • S Sakiyama
    • M Tagawa
  • View Affiliations

  • Published online on: June 1, 1999     https://doi.org/10.3892/ijo.14.6.1081
  • Pages: 1081-1086
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Abstract

The status of the p53 gene of tumor cells can modify the sensitivity of the tumors to radiation and anti-cancer agents. Human esophageal cancer cells (T.Tn) bearing mutated p53 gene were retrovirally transduced with wild-type p53 gene. The transduced cells (T.Tn/p53) which stably expressed wild-type p53 proliferated at the same rate as parental cells. However, the sensitivity to radiation was significantly improved by the transduction and T.Tn/p53 cells became markedly susceptible to cisplatin and etoposide compared with parental cells. Administration of cisplatin noticeably suppressed the growth of T.Tn/p53 tumors but not T.Tn tumors inoculated in nude mice. Forced expression of wild-type p53 gene thereby can increase the sensitivity to DNA damage in esophageal cells.

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Jun 1999
Volume 14 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Matsubara, H., Kimura, M., Sugaya, M., Koide, Y., Gunji, Y., Takegana, K. ... Tagawa, M. (1999). Expression of wild-type p53 gene confers increased sensitivity to radiation and chemotherapeutic agents in human esophageal carcinoma cells.. International Journal of Oncology, 14, 1081-1086. https://doi.org/10.3892/ijo.14.6.1081
MLA
Matsubara, H., Kimura, M., Sugaya, M., Koide, Y., Gunji, Y., Takegana, K., Asano, T., Ochiai, T., Isono, K., Sakiyama, S., Tagawa, M."Expression of wild-type p53 gene confers increased sensitivity to radiation and chemotherapeutic agents in human esophageal carcinoma cells.". International Journal of Oncology 14.6 (1999): 1081-1086.
Chicago
Matsubara, H., Kimura, M., Sugaya, M., Koide, Y., Gunji, Y., Takegana, K., Asano, T., Ochiai, T., Isono, K., Sakiyama, S., Tagawa, M."Expression of wild-type p53 gene confers increased sensitivity to radiation and chemotherapeutic agents in human esophageal carcinoma cells.". International Journal of Oncology 14, no. 6 (1999): 1081-1086. https://doi.org/10.3892/ijo.14.6.1081