Temporal and spatial expressions of transforming growth factor-betas and their receptors in epiphyseal growth plate.

  • Authors:
    • S Matsunaga
    • T Yamamoto
    • K Fukumura
  • View Affiliations

  • Published online on: June 1, 1999     https://doi.org/10.3892/ijo.14.6.1063
  • Pages: 1063-1070
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Abstract

The activities of TGF-beta and its receptors in enchondral ossification have not yet been fully elucidated. The temporal and spatial expressions of TGF-beta and its receptors were examined immunohistochemically in epiphyseal growth plate of rats, in order to clarify the roles of TGF-beta and receptors in cartilage cells during enchondral ossification. TGF-beta1 and TGF-beta3 were expressed from 6 to 24 weeks in resting, proliferating, and maturing zone. TGF-beta2 was expressed at 6 week, but decreased during growth. The expression of TGF-betas in hypertrophic chondrocytes was weak. TbetaR-I was co-expressed with the ligand in resting, proliferating, and maturing zone throughout the development. The expressions of TbetaR-II was recognized at 6 weeks but decreased after that. This study suggests that TGF-betas play a major role in modulating endochondral ossification during growth in epiphyseal growth plate.

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Jun 1999
Volume 14 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Matsunaga, S., Yamamoto, T., & Fukumura, K. (1999). Temporal and spatial expressions of transforming growth factor-betas and their receptors in epiphyseal growth plate.. International Journal of Oncology, 14, 1063-1070. https://doi.org/10.3892/ijo.14.6.1063
MLA
Matsunaga, S., Yamamoto, T., Fukumura, K."Temporal and spatial expressions of transforming growth factor-betas and their receptors in epiphyseal growth plate.". International Journal of Oncology 14.6 (1999): 1063-1070.
Chicago
Matsunaga, S., Yamamoto, T., Fukumura, K."Temporal and spatial expressions of transforming growth factor-betas and their receptors in epiphyseal growth plate.". International Journal of Oncology 14, no. 6 (1999): 1063-1070. https://doi.org/10.3892/ijo.14.6.1063