Detection of DNA polymorphisms and point mutations of high-affinity nerve growth factor receptor (TrkA) in human neuroblastoma.

  • Authors:
    • P Scaruffi
    • R Cusano
    • M Dagnino
    • G P Tonini
  • View Affiliations

  • Published online on: May 1, 1999     https://doi.org/10.3892/ijo.14.5.935
  • Pages: 935-943
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Abstract

We have studied nerve growth factor (NGF) receptors in 63 neuroblastoma tissues. We found DNA polymorphisms of TrkA consisting in C-->T transitions in tyrosine kinase domain at 6773, 7232 and 7301 nucleotides. Both C/T alleles were detected in tumors belonging to patients at stages 1, 2, 3 and 4 but not in 4S that expresses only the allele with C-->T. Furthermore, we detected a GT transversion resulting in a Gly-->Val substitution in a stage 4 and a stage 4S samples. We report the first evidence of TrkA polymorphism and point mutations in neuroblastoma.

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May 1999
Volume 14 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Scaruffi, P., Cusano, R., Dagnino, M., & Tonini, G. (1999). Detection of DNA polymorphisms and point mutations of high-affinity nerve growth factor receptor (TrkA) in human neuroblastoma.. International Journal of Oncology, 14, 935-943. https://doi.org/10.3892/ijo.14.5.935
MLA
Scaruffi, P., Cusano, R., Dagnino, M., Tonini, G."Detection of DNA polymorphisms and point mutations of high-affinity nerve growth factor receptor (TrkA) in human neuroblastoma.". International Journal of Oncology 14.5 (1999): 935-943.
Chicago
Scaruffi, P., Cusano, R., Dagnino, M., Tonini, G."Detection of DNA polymorphisms and point mutations of high-affinity nerve growth factor receptor (TrkA) in human neuroblastoma.". International Journal of Oncology 14, no. 5 (1999): 935-943. https://doi.org/10.3892/ijo.14.5.935