Antitumor effect of electrochemotherapy on colorectal carcinoma in an orthotopic mouse model.

  • Authors:
    • S Kuriyama
    • M Kikukawa
    • A Mitoro
    • H Tsujinoue
    • T Nakatani
    • M Yamazaki
    • H Yoshiji
    • Y Toyokawa
    • M Yoshikawa
    • H Fukui
  • View Affiliations

  • Published online on: February 1, 1999     https://doi.org/10.3892/ijo.14.2.321
  • Pages: 321-327
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Abstract

Electropermeabilization was shown to markedly increase the sensitivity of murine colorectal carcinoma (CRC) cells to bleomycin (BLM), resulting in more than 2,500-fold higher susceptibility to BLM. Subsequent in vivo electrochemotherapy with BLM revealed profound antitumor effects on subcutaneous CRC tumors. Furthermore, when electrochemotherapy with BLM was employed for the treatment of orthotopic CRC tumors in mice, significantly prolonged survival priods were observed. These results indicate the feasibility of electrochemotherapy with BLM for the treatment of CRC and demonstrate that electrochemotherapy can be translated from the treatment of cutaneous and subcutaneous tumors to the treatment of internal cancers including CRC.

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February 1999
Volume 14 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
APA
Kuriyama, S., Kikukawa, M., Mitoro, A., Tsujinoue, H., Nakatani, T., Yamazaki, M. ... Fukui, H. (1999). Antitumor effect of electrochemotherapy on colorectal carcinoma in an orthotopic mouse model.. International Journal of Oncology, 14, 321-327. https://doi.org/10.3892/ijo.14.2.321
MLA
Kuriyama, S., Kikukawa, M., Mitoro, A., Tsujinoue, H., Nakatani, T., Yamazaki, M., Yoshiji, H., Toyokawa, Y., Yoshikawa, M., Fukui, H."Antitumor effect of electrochemotherapy on colorectal carcinoma in an orthotopic mouse model.". International Journal of Oncology 14.2 (1999): 321-327.
Chicago
Kuriyama, S., Kikukawa, M., Mitoro, A., Tsujinoue, H., Nakatani, T., Yamazaki, M., Yoshiji, H., Toyokawa, Y., Yoshikawa, M., Fukui, H."Antitumor effect of electrochemotherapy on colorectal carcinoma in an orthotopic mouse model.". International Journal of Oncology 14, no. 2 (1999): 321-327. https://doi.org/10.3892/ijo.14.2.321