Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma.

  • Authors:
    • M Serra
    • D Maurici
    • K Scotlandi
    • G Barbanti-Brodano
    • M C Manara
    • S Benini
    • P Picci
    • F Bertoni
    • G Bacci
    • S Sottili
    • N Baldini
  • View Affiliations

  • Published online on: February 1, 1999     https://doi.org/10.3892/ijo.14.2.301
  • Pages: 301-308
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Abstract

The transcription of MDR1 gene may be increased by mutation or loss of function of p53 gene. In this study, we investigated whether in osteosarcoma, the p53 status is correlated with overexpression of the MDR1 gene product P-glycoprotein. The relationship between P-glycoprotein expression and p53 status was analyzed by immunohistochemistry in 64 primary and 11 metastatic high-grade osteosarcomas. In the same series, we also assessed the nuclear accumulation of MDM2 protein, whose binding to p53 protein provides an alternative mechanism of p53 inactivation. No association was found between mutant-p53 and MDM2 nuclear accumulation either with P-glycoprotein expression or with clinical course. Only increased expression of P-glycoprotein in tumor cells was significantly associated with a poor outcome, further supporting the adverse prognostic value of this marker in osteosarcoma.

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February 1999
Volume 14 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Serra, M., Maurici, D., Scotlandi, K., Barbanti-Brodano, G., Manara, M., Benini, S. ... Baldini, N. (1999). Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma.. International Journal of Oncology, 14, 301-308. https://doi.org/10.3892/ijo.14.2.301
MLA
Serra, M., Maurici, D., Scotlandi, K., Barbanti-Brodano, G., Manara, M., Benini, S., Picci, P., Bertoni, F., Bacci, G., Sottili, S., Baldini, N."Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma.". International Journal of Oncology 14.2 (1999): 301-308.
Chicago
Serra, M., Maurici, D., Scotlandi, K., Barbanti-Brodano, G., Manara, M., Benini, S., Picci, P., Bertoni, F., Bacci, G., Sottili, S., Baldini, N."Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma.". International Journal of Oncology 14, no. 2 (1999): 301-308. https://doi.org/10.3892/ijo.14.2.301