A novel aromatase inhibitor, vorozole, shows antitumor activity and a decrease of tissue insulin-like growth factor-I level in 7, 12-dimethylbenz[a]anthracene-induced rat mammary tumors.

  • Authors:
    • N Sugamata
    • Y Koibuchi
    • Y Iino
    • Y Morishita
  • View Affiliations

  • Published online on: February 1, 1999     https://doi.org/10.3892/ijo.14.2.259
  • Pages: 259-322
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Abstract

Effects of vorozole, a potent and specific non-steroidal aromatase inhibitor, were evaluated on female Sprague-Dawley (SD) rats with 7, 12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors. Vorozole at a dose of 0.25, 1.0 and 4.0 mg/kg was orally administered once a day for 28 consecutive days. A significant regression in tumor size was observed in each treated group at 1, 2, 3 and 4 weeks after the start of treatment compared with control group. Tissue insulin-like growth factor I (IGF-I) in the DMBA-induced tumors in each treated group significantly decreased in a dose-dependent fashion compared with control group. These results show the mechanism of vorozole in DMBA-induced rat mammary tumors.

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February 1999
Volume 14 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Sugamata, N., Koibuchi, Y., Iino, Y., & Morishita, Y. (1999). A novel aromatase inhibitor, vorozole, shows antitumor activity and a decrease of tissue insulin-like growth factor-I level in 7, 12-dimethylbenz[a]anthracene-induced rat mammary tumors.. International Journal of Oncology, 14, 259-322. https://doi.org/10.3892/ijo.14.2.259
MLA
Sugamata, N., Koibuchi, Y., Iino, Y., Morishita, Y."A novel aromatase inhibitor, vorozole, shows antitumor activity and a decrease of tissue insulin-like growth factor-I level in 7, 12-dimethylbenz[a]anthracene-induced rat mammary tumors.". International Journal of Oncology 14.2 (1999): 259-322.
Chicago
Sugamata, N., Koibuchi, Y., Iino, Y., Morishita, Y."A novel aromatase inhibitor, vorozole, shows antitumor activity and a decrease of tissue insulin-like growth factor-I level in 7, 12-dimethylbenz[a]anthracene-induced rat mammary tumors.". International Journal of Oncology 14, no. 2 (1999): 259-322. https://doi.org/10.3892/ijo.14.2.259