Biodistribution of human MHC non-restricted TALL-104 killer cells in healthy and tumor bearing mice.

  • Authors:
    • A Cesano
    • S Visonneau
    • T Tran
    • D Santoli
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  • Published online on: February 1, 1999     https://doi.org/10.3892/ijo.14.2.245
  • Pages: 245-296
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Abstract

The human cytotoxic T cell line TALL-104 displays potent anti-tumor effects in animals with spontaneous and induced malignancies. We investigated the biodistribution of TALL-104 cells in tumor bearing and healthy mice. 111In-labeled TALL-104 cells, injected intravenously, localized primarily in the lungs for the first 2 h, and redistributed to liver, spleen, and kidneys in the following 24 h both in immunodeficient and immunocompetent mice. TALL-104 cells consistently accumulated in the tumor and at sites of metastases. In animals injected with free 111In-oxine, most of the radioactivity remained in the blood pool with no significant organ accumulation. These data support the tumor homing properties of TALL-104 cells, information which is crucial to their therapeutic efficacy in forthcoming clinical trials.

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February 1999
Volume 14 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Cesano, A., Visonneau, S., Tran, T., & Santoli, D. (1999). Biodistribution of human MHC non-restricted TALL-104 killer cells in healthy and tumor bearing mice.. International Journal of Oncology, 14, 245-296. https://doi.org/10.3892/ijo.14.2.245
MLA
Cesano, A., Visonneau, S., Tran, T., Santoli, D."Biodistribution of human MHC non-restricted TALL-104 killer cells in healthy and tumor bearing mice.". International Journal of Oncology 14.2 (1999): 245-296.
Chicago
Cesano, A., Visonneau, S., Tran, T., Santoli, D."Biodistribution of human MHC non-restricted TALL-104 killer cells in healthy and tumor bearing mice.". International Journal of Oncology 14, no. 2 (1999): 245-296. https://doi.org/10.3892/ijo.14.2.245