Regulation of cell proliferation and urokinase plasminogen activation of human breast epithelial cells by carrageenans.

  • Authors:
    • V Lambrecht
    • B Boilly
    • X Le Bourhis
  • View Affiliations

  • Published online on: June 1, 1998     https://doi.org/10.3892/ijo.12.6.1397
  • Pages: 1397-1798
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Abstract

Carrageenans, a family of polysulphated carbohydrates, are able to inhibit the binding to cells of growth factors such as transforming growth factor 1 (TGF 1), fibroblast growth factor-2 (FGF-2) and platelet-derived growth factor (PDGF) and so modulate cell invasion and proliferation. We studied the effects of carrageenans on the proliferation and on the uPA/PAI-1 system in breast epithelial cells. Carrageenans were able to inhibit the proliferation of both normal breast epithelial cells (NBEC) and breast epithelial cancer cell lines (MDA-MB-231 and MCF-7) but could only inhibit the uPA activity in the MDA-MB-231 cells. Moreover, carrageenans inhibited FGF-2 binding in all three cell types, suggesting that they regulate cell proliferation and uPA/PAI-1 system through two distinct mechanisms. These molecules could be considered as potentially useful anti-cancer agents.

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June 1998
Volume 12 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Lambrecht, V., Boilly, B., & Le Bourhis, X. (1998). Regulation of cell proliferation and urokinase plasminogen activation of human breast epithelial cells by carrageenans.. International Journal of Oncology, 12, 1397-1798. https://doi.org/10.3892/ijo.12.6.1397
MLA
Lambrecht, V., Boilly, B., Le Bourhis, X."Regulation of cell proliferation and urokinase plasminogen activation of human breast epithelial cells by carrageenans.". International Journal of Oncology 12.6 (1998): 1397-1798.
Chicago
Lambrecht, V., Boilly, B., Le Bourhis, X."Regulation of cell proliferation and urokinase plasminogen activation of human breast epithelial cells by carrageenans.". International Journal of Oncology 12, no. 6 (1998): 1397-1798. https://doi.org/10.3892/ijo.12.6.1397