Matrix metalloproteinases in cancer: prognostic markers and targets for therapy (review).

  • Authors:
    • M J Duffy
    • K McCarthy
  • View Affiliations

  • Published online on: June 1, 1998     https://doi.org/10.3892/ijo.12.6.1343
  • Pages: 1343-1351
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Abstract

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases which catalyse degradation of diverse substrates in the extracellular matrix. The family can be loosely divided into 4 subgroups, i.e., interstitial collagenases, gelatinases, stromelysins and membrane-type MMPs. Data from model systems suggest that MMPs are involved in both stimulating tumor cell growth and promoting invasion and metastasis. Consistent with their role in tumor progression, high levels of certain MMPs have been shown to correlate with poor prognosis in different human cancers. Inhibitors of MMPs prevent or decrease tumor progression in model systems and are currently undergoing evaluation for the treatment of human cancers.

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June 1998
Volume 12 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Duffy, M., & Duffy, M. (1998). Matrix metalloproteinases in cancer: prognostic markers and targets for therapy (review).. International Journal of Oncology, 12, 1343-1351. https://doi.org/10.3892/ijo.12.6.1343
MLA
Duffy, M., McCarthy, K."Matrix metalloproteinases in cancer: prognostic markers and targets for therapy (review).". International Journal of Oncology 12.6 (1998): 1343-1351.
Chicago
Duffy, M., McCarthy, K."Matrix metalloproteinases in cancer: prognostic markers and targets for therapy (review).". International Journal of Oncology 12, no. 6 (1998): 1343-1351. https://doi.org/10.3892/ijo.12.6.1343