Involvement of caspase family proteases in FPT inhibitor III-induced apoptosis in human ovarian cancer cells.

  • Authors:
    • W C Hung
    • L Y Chuang
  • View Affiliations

  • Published online on: June 1, 1998     https://doi.org/10.3892/ijo.12.6.1339
  • Pages: 1339-1381
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

We have previously demonstrated that a new farnesyltransferase inhibitor, FPT inhibitor III, triggers apoptosis in human ovarian cancer cells. Here, we report that induction of apoptotic cell death in PA-1 ovarian cancer cells by FPT inhibitor III was accompanied by the activation of interleukin-1 #-converting enzyme (ICE)-like proteases, which have recently been renamed as caspases. The caspase inhibitor, ZVAD-FMK, which inhibits a number of caspase family proteases, blocked FPT inhibitor III-induced apoptotic cell death in a dose-dependent manner. Additionally, cleavage of poly(ADP-ribose) polymerase, an identified in vivo substrate for caspase family proteases, in FPT inhibitor III-treated cells was confirmed by immunoblotting. Our results suggest that the caspase family proteases are involved in the induction of apoptosis triggered by FPT inhibitor III.

Related Articles

Journal Cover

June 1998
Volume 12 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Hung, W., & Hung, W. (1998). Involvement of caspase family proteases in FPT inhibitor III-induced apoptosis in human ovarian cancer cells.. International Journal of Oncology, 12, 1339-1381. https://doi.org/10.3892/ijo.12.6.1339
MLA
Hung, W., Chuang, L."Involvement of caspase family proteases in FPT inhibitor III-induced apoptosis in human ovarian cancer cells.". International Journal of Oncology 12.6 (1998): 1339-1381.
Chicago
Hung, W., Chuang, L."Involvement of caspase family proteases in FPT inhibitor III-induced apoptosis in human ovarian cancer cells.". International Journal of Oncology 12, no. 6 (1998): 1339-1381. https://doi.org/10.3892/ijo.12.6.1339