The herbal medicine sho-saiko-to inhibits the growth of malignant melanoma cells by upregulating Fas-mediated apoptosis and arresting cell cycle through downregulation of cyclin dependent kinases.

  • Authors:
    • W Liu
    • M Kato
    • A A Akhand
    • A Hayakawa
    • M Takemura
    • S Yoshida
    • H Suzuki
    • I Nakashima
  • View Affiliations

  • Published online on: June 1, 1998     https://doi.org/10.3892/ijo.12.6.1321
  • Pages: 1321-1327
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Abstract

The anti-tumor effect and its mechanism of the herbal medicine sho-saiko-to were investigated on a murine malignant melanoma cell line (Mel-ret). Sho-saiko-to induced apoptotic cell death of Mel-ret cells with a definite increase of cell surface Fas antigen and Fas ligand (FasL). Sho-saiko-to arrested Mel-ret cells in G1 phase by decreasing the expression of cyclin-dependent kinase (cdk) 4 and its homologue cdk6. Kinase activities of cdk4 and cdk6 were identified to be downregulated by sho-saiko-to. Ingredient analysis revealed that baicalin is likely the main active constituent in the upregulation of Fas antigen and Fas ligand, while glycyrrhizin is the main constituent in the inhibition of cdks.

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June 1998
Volume 12 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Liu, W., Kato, M., Akhand, A., Hayakawa, A., Takemura, M., Yoshida, S. ... Nakashima, I. (1998). The herbal medicine sho-saiko-to inhibits the growth of malignant melanoma cells by upregulating Fas-mediated apoptosis and arresting cell cycle through downregulation of cyclin dependent kinases.. International Journal of Oncology, 12, 1321-1327. https://doi.org/10.3892/ijo.12.6.1321
MLA
Liu, W., Kato, M., Akhand, A., Hayakawa, A., Takemura, M., Yoshida, S., Suzuki, H., Nakashima, I."The herbal medicine sho-saiko-to inhibits the growth of malignant melanoma cells by upregulating Fas-mediated apoptosis and arresting cell cycle through downregulation of cyclin dependent kinases.". International Journal of Oncology 12.6 (1998): 1321-1327.
Chicago
Liu, W., Kato, M., Akhand, A., Hayakawa, A., Takemura, M., Yoshida, S., Suzuki, H., Nakashima, I."The herbal medicine sho-saiko-to inhibits the growth of malignant melanoma cells by upregulating Fas-mediated apoptosis and arresting cell cycle through downregulation of cyclin dependent kinases.". International Journal of Oncology 12, no. 6 (1998): 1321-1327. https://doi.org/10.3892/ijo.12.6.1321