Elevated concentrations of mitochondrial peripheral benzodiazepine receptors in ovarian tumors.

  • Authors:
    • S Batra
    • C S Iosif
  • View Affiliations

  • Published online on: June 1, 1998     https://doi.org/10.3892/ijo.12.6.1295
  • Pages: 1295-1303
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Abstract

Using PK 11195, a high affinity ligand for peripheral benzodiazepine receptor (PBZr) binding sites in isolated mitochondria (m-fraction) and microsomal fraction (p-fraction) from human ovaries and ovarian tumors were studied. Binding in both m and p-fractions from ovaries and tumors were saturable and of high affinity. The PBZr density in m- and p-fractions from ovaries was very similar whereas the binding in m-fraction in ovarian tumors was nearly 3-fold higher than p-fraction. There was no significant difference in the binding affinities (KD values) for PK 11195 in the various fractions. The selective increase in the density of PBZr in mitochondria of tumors suggests an association with energy demand and utilization. The role of a relatively high density of PBZr in microsomal fractions remains to be elucidated.

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June 1998
Volume 12 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Batra, S., & Batra, S. (1998). Elevated concentrations of mitochondrial peripheral benzodiazepine receptors in ovarian tumors.. International Journal of Oncology, 12, 1295-1303. https://doi.org/10.3892/ijo.12.6.1295
MLA
Batra, S., Iosif, C."Elevated concentrations of mitochondrial peripheral benzodiazepine receptors in ovarian tumors.". International Journal of Oncology 12.6 (1998): 1295-1303.
Chicago
Batra, S., Iosif, C."Elevated concentrations of mitochondrial peripheral benzodiazepine receptors in ovarian tumors.". International Journal of Oncology 12, no. 6 (1998): 1295-1303. https://doi.org/10.3892/ijo.12.6.1295