Cytogenetic analysis of de novo acute myeloid leukemia with trilineage myelodysplasia in comparison with myelodysplastic syndrome evolving to acute myeloid leukemia.

  • Authors:
    • S Tamura
    • Y Takemoto
    • T Hashimoto-Tamaoki
    • K Mimura
    • Y Sugahara
    • J Senoh
    • J I Furuyama
    • E Kakishita
  • View Affiliations

  • Published online on: June 1, 1998     https://doi.org/10.3892/ijo.12.6.1259
  • Pages: 1259-1321
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Abstract

Characteristics of karyotypes were analyzed in de novo acute myeloid leukemia (AML) with trilineage myelodysplasia (AML/TMDS) at initial diagnosis and compared with myelodysplastic syndrome (MDS) cases that had evolved to AML (MDS/AML). Abnormal karyotypes were seen in 11 of 19 patients with AML/TMDS and 13 of 16 MDS/AML cases. Trisomy 8 was observed in 3 AML/TMDS cases as a sole anomaly and was also present in 3 MDS/AML cases but not as a sole finding. Although MDS/AML frequently displayed monosomies or long-arm deletions of chromosome 5, 7 and 9, only one case exhibited long-arm deletion (of chromosome 7) in AML/TMDS. Two or more chromosome aberrations were found in some cases in both groups. These findings suggest that AML/TMDS had passed through several preleukemic stages at diagnosis, as has been well documented in MDS and MDS/AML. Additionally, clonal evolution may have already occurred in AML/TMDS, as MDS transformed to AML is associated with clonal evolution.

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June 1998
Volume 12 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Tamura, S., Takemoto, Y., Hashimoto-Tamaoki, T., Mimura, K., Sugahara, Y., Senoh, J. ... Kakishita, E. (1998). Cytogenetic analysis of de novo acute myeloid leukemia with trilineage myelodysplasia in comparison with myelodysplastic syndrome evolving to acute myeloid leukemia.. International Journal of Oncology, 12, 1259-1321. https://doi.org/10.3892/ijo.12.6.1259
MLA
Tamura, S., Takemoto, Y., Hashimoto-Tamaoki, T., Mimura, K., Sugahara, Y., Senoh, J., Furuyama, J., Kakishita, E."Cytogenetic analysis of de novo acute myeloid leukemia with trilineage myelodysplasia in comparison with myelodysplastic syndrome evolving to acute myeloid leukemia.". International Journal of Oncology 12.6 (1998): 1259-1321.
Chicago
Tamura, S., Takemoto, Y., Hashimoto-Tamaoki, T., Mimura, K., Sugahara, Y., Senoh, J., Furuyama, J., Kakishita, E."Cytogenetic analysis of de novo acute myeloid leukemia with trilineage myelodysplasia in comparison with myelodysplastic syndrome evolving to acute myeloid leukemia.". International Journal of Oncology 12, no. 6 (1998): 1259-1321. https://doi.org/10.3892/ijo.12.6.1259