Expression of CD44 containing variant exon 9 (CD44v9) in gastric adenomas and adenocarcinomas: relation to the proliferation and progression.

  • Authors:
    • W Yasui
    • Y Kudo
    • K Naka
    • J Fujimoto
    • T Ue
    • H Yokozaki
    • E Tahara
  • View Affiliations

  • Published online on: June 1, 1998     https://doi.org/10.3892/ijo.12.6.1253
  • Pages: 1253-1261
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Abstract

The expression of CD44 splice variant containing exon 14 (variant exon 9: CD44v9) was examined immunohistochemically in non-neoplastic mucosa, adenoma and adenocarcinoma of the stomach and analyzed the relation with the expression of Ki-67 antigen and p53 protein. In non-neoplastic gastric mucosa, basolateral membrane of the epithelial cells in the pyloric glands showed the expression of CD44v9. The epithelial cells in the intestinal metaplastic mucosa of the stomach sometimes expressed CD44v9. In the neoplastic lesions, the expression of CD44v9 was detected in 20% (34/170) of the adenomas and 28% (132/478) of the adenocarcinomas, respectively. The incidence of CD44v9 expression did not differ among histological type of gastric carcinoma. Twelve per cent of the adenocarcinomas showed strong expression of CD44v9, whereas non of the adenomas did. The incidence of CD44v9 expression was significantly higher in carcinomas invading into muscularis propria or the cases of stages 3 and 4 in comparison with that in carcinomas limited to submucosa or the stages 1 and 2 cases (p<0.05). The incidence of positive cases was higher in carcinomas with lymph node metastasis than those without metastasis (p<0.05). The expression of CD44v9 was significantly correlated with the expression of Ki-67 (p<0.05). It was also correlated with the expression of p53 protein in the tumor cells (p<0.01). These findings overall suggest that the expression of CD44v9 may be associated with the development as well as progression of the gastric carcinomas.

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June 1998
Volume 12 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Yasui, W., Kudo, Y., Naka, K., Fujimoto, J., Ue, T., Yokozaki, H., & Tahara, E. (1998). Expression of CD44 containing variant exon 9 (CD44v9) in gastric adenomas and adenocarcinomas: relation to the proliferation and progression.. International Journal of Oncology, 12, 1253-1261. https://doi.org/10.3892/ijo.12.6.1253
MLA
Yasui, W., Kudo, Y., Naka, K., Fujimoto, J., Ue, T., Yokozaki, H., Tahara, E."Expression of CD44 containing variant exon 9 (CD44v9) in gastric adenomas and adenocarcinomas: relation to the proliferation and progression.". International Journal of Oncology 12.6 (1998): 1253-1261.
Chicago
Yasui, W., Kudo, Y., Naka, K., Fujimoto, J., Ue, T., Yokozaki, H., Tahara, E."Expression of CD44 containing variant exon 9 (CD44v9) in gastric adenomas and adenocarcinomas: relation to the proliferation and progression.". International Journal of Oncology 12, no. 6 (1998): 1253-1261. https://doi.org/10.3892/ijo.12.6.1253