Prognostic implications of loss of heterozygosity in the 17q21 region in breast cancer

  • Authors:
    • B Gomendio
    • J Silva
    • M Provencio
    • J Garcia
    • E GarciaPatino
    • C GarciaAndrade
    • L Carretero
    • P Espana
    • F Bonilla
  • View Affiliations

  • Published online on: March 1, 1997     https://doi.org/10.3892/ijo.10.3.659
  • Pages: 659-663
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Abstract

Sporadic breast cancer is the commonest form of this malignancy. Genetic changes are frequent events in breast cancer. We investigated the implication of LOH in the 17q21 region as a prognostic factor in this disease. Fifty-three patients were studied and 14 clinico-pathological parameters were evaluated for comparison between the patients with LOH and patients without LOH. A LOH rate of 21% was found and, upon comparison of the two subgroups, a significantly lower rate of recurrence after adjuvant chemotherapy in patients with LOH was observed. This suggests that LOH occurring in this region in breast cancer could help to design new adjuvant treatment strategies.

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March 1997
Volume 10 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Gomendio, B., Silva, J., Provencio, M., Garcia, J., GarciaPatino, E., GarciaAndrade, C. ... Bonilla, F. (1997). Prognostic implications of loss of heterozygosity in the 17q21 region in breast cancer. International Journal of Oncology, 10, 659-663. https://doi.org/10.3892/ijo.10.3.659
MLA
Gomendio, B., Silva, J., Provencio, M., Garcia, J., GarciaPatino, E., GarciaAndrade, C., Carretero, L., Espana, P., Bonilla, F."Prognostic implications of loss of heterozygosity in the 17q21 region in breast cancer". International Journal of Oncology 10.3 (1997): 659-663.
Chicago
Gomendio, B., Silva, J., Provencio, M., Garcia, J., GarciaPatino, E., GarciaAndrade, C., Carretero, L., Espana, P., Bonilla, F."Prognostic implications of loss of heterozygosity in the 17q21 region in breast cancer". International Journal of Oncology 10, no. 3 (1997): 659-663. https://doi.org/10.3892/ijo.10.3.659