Expression of matrix metalloproteinases 1 and 2 genes in a possible association with metastatic abilities of human pancreatic cancer cells

  • Authors:
    • S Jimi
    • T Shono
    • M Ono
    • M Kuwano
    • M Tanaka
    • C LopezOtin
    • A Kono
  • View Affiliations

  • Published online on: March 1, 1997     https://doi.org/10.3892/ijo.10.3.623
  • Pages: 623-628
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Abstract

We determined if any extracellular matrix degradative proteases were possibly associated with metastatic potentials of human pancreatic cancer cells. Liver metastatic abilities of six human pancreatic cancer cell lines were examined in nude mice, and divided into two high (2 lines) and low (4 lines) metastatic cell lines. Of six cell lines, matrix metalloproteinases-1 (MMP-1) was overexpressed in two high metastatic cell lines: and MMP-2 was overexpressed in one high metastatic cell line. Of the four low metastatic lines, two cell lines had relatively higher mRNA levels of tissue inhibitors of metalloproteinases-3 (TIMP-3). MMP activities due to MMP-1 and MMP-2 might be positively associated with liver metastasis of pancreatic cancer cells. Moreover, expression of TIMP-3 might be partly involved in the low metastatic potentials of pancreatic cancer.

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March 1997
Volume 10 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Jimi, S., Shono, T., Ono, M., Kuwano, M., Tanaka, M., LopezOtin, C., & Kono, A. (1997). Expression of matrix metalloproteinases 1 and 2 genes in a possible association with metastatic abilities of human pancreatic cancer cells. International Journal of Oncology, 10, 623-628. https://doi.org/10.3892/ijo.10.3.623
MLA
Jimi, S., Shono, T., Ono, M., Kuwano, M., Tanaka, M., LopezOtin, C., Kono, A."Expression of matrix metalloproteinases 1 and 2 genes in a possible association with metastatic abilities of human pancreatic cancer cells". International Journal of Oncology 10.3 (1997): 623-628.
Chicago
Jimi, S., Shono, T., Ono, M., Kuwano, M., Tanaka, M., LopezOtin, C., Kono, A."Expression of matrix metalloproteinases 1 and 2 genes in a possible association with metastatic abilities of human pancreatic cancer cells". International Journal of Oncology 10, no. 3 (1997): 623-628. https://doi.org/10.3892/ijo.10.3.623