Non-coexpression of collagenase and transin in malignant epithelial cells

  • Authors:
    • M Paine
    • J Gibbins
    • R Kefford
  • View Affiliations

  • Published online on: March 1, 1997     https://doi.org/10.3892/ijo.10.3.615
  • Pages: 615-618
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Abstract

Increased synthesis and secretion of the matrix metalloproteinase has been associated with the acquisition of the invasive properties of malignant cells. In a rat malignant anaplastic cell line (T952/F7) sporadic expression of mRNA for collagenase-3 against a background of high transin-l mRNA has been shown. Sporadic induction of either metalloproteinase was not found in the benign precursor cells (A5P/B10) of T952/F7 cells, but a coordinate mRNA induction profile for these two genes could be induced by the addition of 12-O-tetradecanoylphorbol-13-acetate. In a different uncloned neoplastic epithelial cell line (BCl) fluctuations in the levels of collagenase and transin appeared coordinately, but coordinate expression was not a feature in cloned lines derived from BCl. The loss of coordinate regulation of the two matrix metalloproteinases may relate to the variability in metastatic potential seen in clonal cell lines.

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March 1997
Volume 10 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Paine, M., Gibbins, J., & Kefford, R. (1997). Non-coexpression of collagenase and transin in malignant epithelial cells. International Journal of Oncology, 10, 615-618. https://doi.org/10.3892/ijo.10.3.615
MLA
Paine, M., Gibbins, J., Kefford, R."Non-coexpression of collagenase and transin in malignant epithelial cells". International Journal of Oncology 10.3 (1997): 615-618.
Chicago
Paine, M., Gibbins, J., Kefford, R."Non-coexpression of collagenase and transin in malignant epithelial cells". International Journal of Oncology 10, no. 3 (1997): 615-618. https://doi.org/10.3892/ijo.10.3.615