Local hyperthermia, hyperfractionated radiation, and cisplatin in preirradiated recurrent lymph node metastases of recurrent head and neck cancer

  • Authors:
    • T Feyerabend
    • R Steeves
    • B Jager
    • G Wiedemann
    • K Sommer
    • E Richter
    • D Katschinski
    • H Robins
  • View Affiliations

  • Published online on: March 1, 1997     https://doi.org/10.3892/ijo.10.3.591
  • Pages: 591-595
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Abstract

Large tumor size is a negative prognostic variable for attaining complete regression (CR) with local hyperthermia (HT) and radiotherapy (RT). Such poor prognosis lesions (i.e., >7 cm(2) or >14 cm(3)) have an expected CR rate of similar to 30+/-8%. To improve on this result we added cisplatin to HT and RT with standard fractionation (std Fx) in an earlier study, and observed a 19% CR rate in head and neck (H&N) patients. We now report the results of a second generation trial combining HT, cisplatin (40 mg/m(2)) and hyperfractionated RT in a series of 13 pretreated poor prognosis H&N patients. Therapy encompassed 44 triple modality sessions and was well tolerated: toxicity included one episode of grade-3 skin reaction and one grade 1 leukopenia. Although the overall remission rate was 92%, the CR rate was only 8%; this resulted in early closure of this trial concluding that hyperfractionated RT had no (over std Fx RT) benefit in this combined modality approach.

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March 1997
Volume 10 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Feyerabend, T., Steeves, R., Jager, B., Wiedemann, G., Sommer, K., Richter, E. ... Robins, H. (1997). Local hyperthermia, hyperfractionated radiation, and cisplatin in preirradiated recurrent lymph node metastases of recurrent head and neck cancer. International Journal of Oncology, 10, 591-595. https://doi.org/10.3892/ijo.10.3.591
MLA
Feyerabend, T., Steeves, R., Jager, B., Wiedemann, G., Sommer, K., Richter, E., Katschinski, D., Robins, H."Local hyperthermia, hyperfractionated radiation, and cisplatin in preirradiated recurrent lymph node metastases of recurrent head and neck cancer". International Journal of Oncology 10.3 (1997): 591-595.
Chicago
Feyerabend, T., Steeves, R., Jager, B., Wiedemann, G., Sommer, K., Richter, E., Katschinski, D., Robins, H."Local hyperthermia, hyperfractionated radiation, and cisplatin in preirradiated recurrent lymph node metastases of recurrent head and neck cancer". International Journal of Oncology 10, no. 3 (1997): 591-595. https://doi.org/10.3892/ijo.10.3.591