Bcl-2 protein expression in breast cancer and its relationship to prognosis

  • Authors:
    • A Yamaguchi
    • M Maehara
    • T Goi
    • K Katayama
    • K Hirose
    • G Nakagawara
  • View Affiliations

  • Published online on: March 1, 1997     https://doi.org/10.3892/ijo.10.3.581
  • Pages: 581-584
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The expression of bcl-2 protein was studied in invasive breast cancer by immunohistochemistry. Fourty-six (56.8%) bcl-2 protein-positive tumors were found in 81 breast cancers. There was no significant correlation between the bcl-2 protein immunoreactivity and histologic type, primary tumor status, or lymph node metastasis. However, a strong positive relationship was demonstrated between bcl-2 immunoreactivity and estrogen receptor status. The 5-year survival rate and disease-free survival rates were 73.7% and 71.1% of patients with bcl-2-positive tumors, and 62.5% and 58.0% of those with bcl-2-negative tumors; these differences between the two groups of patients wete significant (p<0.05). In multivariate analysis using Cox regression model, bcl-2 immunoreactivity emerged as an independent prognostic indicator in breast cancer patients.

Related Articles

Journal Cover

March 1997
Volume 10 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Yamaguchi, A., Maehara, M., Goi, T., Katayama, K., Hirose, K., & Nakagawara, G. (1997). Bcl-2 protein expression in breast cancer and its relationship to prognosis. International Journal of Oncology, 10, 581-584. https://doi.org/10.3892/ijo.10.3.581
MLA
Yamaguchi, A., Maehara, M., Goi, T., Katayama, K., Hirose, K., Nakagawara, G."Bcl-2 protein expression in breast cancer and its relationship to prognosis". International Journal of Oncology 10.3 (1997): 581-584.
Chicago
Yamaguchi, A., Maehara, M., Goi, T., Katayama, K., Hirose, K., Nakagawara, G."Bcl-2 protein expression in breast cancer and its relationship to prognosis". International Journal of Oncology 10, no. 3 (1997): 581-584. https://doi.org/10.3892/ijo.10.3.581