Viral gene mutation as determinant of low grade malignancy of lesions induced by perinatal retrovirus infection

  • Authors:
    • S Lu
    • M Miyauchi
    • K Maruyama
  • View Affiliations

  • Published online on: March 1, 1997     https://doi.org/10.3892/ijo.10.3.539
  • Pages: 539-544
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Abstract

Of 108 Wistar/Ma rats perinatally injected with Snyder-Theilen feline sarcoma virus, 75 developed tumors within 60 days (group A), and 25 after more than 117 days (group B). Metastases were detected in 59.1% and 11.8% in group A and B respectively. Antibody to v-fes gene product was found to occur before tumor development in group B and after tumor development in group A. v-Ses was found to be down-regulated and extensively mutated in tumors of group B. These results suggest viral gene mutation as a determinant of low grade malignancy of lesions induced.

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March 1997
Volume 10 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Lu, S., Miyauchi, M., & Maruyama, K. (1997). Viral gene mutation as determinant of low grade malignancy of lesions induced by perinatal retrovirus infection. International Journal of Oncology, 10, 539-544. https://doi.org/10.3892/ijo.10.3.539
MLA
Lu, S., Miyauchi, M., Maruyama, K."Viral gene mutation as determinant of low grade malignancy of lesions induced by perinatal retrovirus infection". International Journal of Oncology 10.3 (1997): 539-544.
Chicago
Lu, S., Miyauchi, M., Maruyama, K."Viral gene mutation as determinant of low grade malignancy of lesions induced by perinatal retrovirus infection". International Journal of Oncology 10, no. 3 (1997): 539-544. https://doi.org/10.3892/ijo.10.3.539