Allelic imbalance on the long arm of chromosome 5 in oral squamous cell carcinoma

  • Authors:
    • X Wang
    • K Uzawa
    • H Nakanishi
    • H Tanzawa
    • K Sato
  • View Affiliations

  • Published online on: March 1, 1997     https://doi.org/10.3892/ijo.10.3.535
  • Pages: 535-538
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

To obtain a more detailed estimate of chromosome 5 loci involvement in oral squamous cell carcinoma (SCC), thirty-two oral SCCs were examined for loss of heterozygosity (LOH) on the long arm of chromosome 5 (5q) by PCR-LOH assay using thirteen microsatellite markers. LOH was observed in 16 (51.6%) of 31 informative cases. The incidence or the number of regions showing LOH was significantly higher in moderately and poorly differentiated tumors than in the well differentiated ones. Among the loci tested, D5S178 exhibited LOH in 11 (39.3%) of 28 cases, suggesting this to be the site, at 5q, of a novel candidate tumor suppressor gene. These data indicate that the incidence of LOH at chromosome 5q is high and is associated with oral tumor differentiation.

Related Articles

Journal Cover

March 1997
Volume 10 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Wang, X., Uzawa, K., Nakanishi, H., Tanzawa, H., & Sato, K. (1997). Allelic imbalance on the long arm of chromosome 5 in oral squamous cell carcinoma. International Journal of Oncology, 10, 535-538. https://doi.org/10.3892/ijo.10.3.535
MLA
Wang, X., Uzawa, K., Nakanishi, H., Tanzawa, H., Sato, K."Allelic imbalance on the long arm of chromosome 5 in oral squamous cell carcinoma". International Journal of Oncology 10.3 (1997): 535-538.
Chicago
Wang, X., Uzawa, K., Nakanishi, H., Tanzawa, H., Sato, K."Allelic imbalance on the long arm of chromosome 5 in oral squamous cell carcinoma". International Journal of Oncology 10, no. 3 (1997): 535-538. https://doi.org/10.3892/ijo.10.3.535