Cyclooxygenase-2 gene expression in human breast cancer

  • Authors:
    • M Parrett
    • R Harris
    • F Joarder
    • M Ross
    • K Clausen
    • F Robertson
  • View Affiliations

  • Published online on: March 1, 1997     https://doi.org/10.3892/ijo.10.3.503
  • Pages: 503-507
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Abstract

Expression of the inducible isoform of the cyclooxygenase gene (PGHS-2, COX-2) which codes for the enzyme that catalyzes formation of prostaglandins, was detected in 13/13 human breast tumors of high grade but not in samples of normal breast tissue. There was a statistically significant linear association between COX-2 gene expression and high (>50%) tumor cell density (p<0.01), with COX-2 protein localized to tumor cells. These results indicate that COX-2 gene expression may be useful as a molecular biomarker for human breast tumors and may also predict sensitivity to treatment with nonsteroidal anti-inflammatory drugs.

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March 1997
Volume 10 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Parrett, M., Harris, R., Joarder, F., Ross, M., Clausen, K., & Robertson, F. (1997). Cyclooxygenase-2 gene expression in human breast cancer. International Journal of Oncology, 10, 503-507. https://doi.org/10.3892/ijo.10.3.503
MLA
Parrett, M., Harris, R., Joarder, F., Ross, M., Clausen, K., Robertson, F."Cyclooxygenase-2 gene expression in human breast cancer". International Journal of Oncology 10.3 (1997): 503-507.
Chicago
Parrett, M., Harris, R., Joarder, F., Ross, M., Clausen, K., Robertson, F."Cyclooxygenase-2 gene expression in human breast cancer". International Journal of Oncology 10, no. 3 (1997): 503-507. https://doi.org/10.3892/ijo.10.3.503