Clinical significance of pyrimidine nucleoside phosphorylase in colorectal carcinoma

  • Authors:
    • K Mimori
    • M Mori
    • T Shiraishi
    • M Haraguchi
    • H Ueo
    • T Akiyoshi
  • View Affiliations

  • Published online on: March 1, 1997     https://doi.org/10.3892/ijo.10.3.493
  • Pages: 493-496
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Abstract

The expression of pyrimidine nucleoside phosphorylase (PyNPase) mRNA in tumor (T) and normal (N) biopsy specimens obtained from 41 cases of colorectal carcinoma was examined by the reverse transcriptase/polymerase chain reaction (RT-PCR). The higher T/N ratio of the expression of PyNPase mRNA correlated significantly with the presence of lymph vessel invasion (p=0.039), the positive lymph node metastasis (p=0.014) and the advanced stage of the disease (p=0.014). There was a significant con-elation between the results determined by enzyme activity and those determined by RT-PCR (p=0.005). The findings suggested that the determination of PyNPase mRNA by RT-PCR may give useful information on tumor aggressiveness of colorectal carcinoma and this method can be used instead of enzyme activity.

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March 1997
Volume 10 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Mimori, K., Mori, M., Shiraishi, T., Haraguchi, M., Ueo, H., & Akiyoshi, T. (1997). Clinical significance of pyrimidine nucleoside phosphorylase in colorectal carcinoma. International Journal of Oncology, 10, 493-496. https://doi.org/10.3892/ijo.10.3.493
MLA
Mimori, K., Mori, M., Shiraishi, T., Haraguchi, M., Ueo, H., Akiyoshi, T."Clinical significance of pyrimidine nucleoside phosphorylase in colorectal carcinoma". International Journal of Oncology 10.3 (1997): 493-496.
Chicago
Mimori, K., Mori, M., Shiraishi, T., Haraguchi, M., Ueo, H., Akiyoshi, T."Clinical significance of pyrimidine nucleoside phosphorylase in colorectal carcinoma". International Journal of Oncology 10, no. 3 (1997): 493-496. https://doi.org/10.3892/ijo.10.3.493