Differences of ploidy status in progression of head and neck melanomas
- M Korabiowska
- U Brinckmann
- S Kellner
- U Brinck
- J Stachura
- A Schauer
Affiliations: UNIV GOTTINGEN,DEPT MED INFORMAT,D-37075 GOTTINGEN,GERMANY. JAGIELLONIAN UNIV,DEPT PATHOL,PL-30561 KRAKOW,POLAND.
- Published online on: February 1, 1997 https://doi.org/10.3892/ijo.10.2.381
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Thirty-three common naevi, 26 dysplastic naevi, 58 primary melanomas of facial skin, 24 oral melanomas, 32 lymph nodes and 12 distant melanoma metastases were stained using Feulgen method to evaluate the ploidy status by image analysis GAS-200 system. Eight percent of common naevi, 22% of dysplastic naevi, 43% of facial melanomas, 65% of oral melanomas, 40% of lymph nodes with melanoma metastases and 66% of distant melanoma metastases were classified as aneuploid. In facial melanomas the percentage of aneuploid cases increased with Clark level. Survival time of patients was significantly shorter for aneuploid cases as compared to euploid ones (p <0.01).