Modulation of growth and urokinase secretion by vasopressin and closely related nonapeptides in metastatic mouse mammary tumor cells

  • Authors:
    • D Alonso
    • G Skilton
    • H Farina
    • M DeLorenzo
    • D Gomez
  • View Affiliations

  • Published online on: February 1, 1997     https://doi.org/10.3892/ijo.10.2.375
  • Pages: 375-379
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Abstract

We examined the effects of the neuropeptide hormones vasopressin and oxytocin, and their respective synthetic derivatives desmopressin and isotocin, on F3II mouse mammary carcinoma cells. Vasopressin and desmopressin at concentrations ranging from 0.1 to 1 mu M were mitogenic for F3II cells and induced protein accumulation. On the contrary, oxytocin and isotocin were moderately growth inhibitory at similar doses. In confluent monolayers vasopressin stimulated the secretion of urokinase, a profibrinolytic enzyme involved in hematogenous metastasis. However, the net effect of the peptide on tumor-derived proteolytic activity was dependent on cell density. Stimulation of cell growth and urokinase production by vasopressin was strongly linked with calcium mobilization. These data suggest that vasopressin and its synthetic analog desmopressin may be important modulators of the behavior of metastatic mammary tumor cells.

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February 1997
Volume 10 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Alonso, D., Skilton, G., Farina, H., DeLorenzo, M., & Gomez, D. (1997). Modulation of growth and urokinase secretion by vasopressin and closely related nonapeptides in metastatic mouse mammary tumor cells. International Journal of Oncology, 10, 375-379. https://doi.org/10.3892/ijo.10.2.375
MLA
Alonso, D., Skilton, G., Farina, H., DeLorenzo, M., Gomez, D."Modulation of growth and urokinase secretion by vasopressin and closely related nonapeptides in metastatic mouse mammary tumor cells". International Journal of Oncology 10.2 (1997): 375-379.
Chicago
Alonso, D., Skilton, G., Farina, H., DeLorenzo, M., Gomez, D."Modulation of growth and urokinase secretion by vasopressin and closely related nonapeptides in metastatic mouse mammary tumor cells". International Journal of Oncology 10, no. 2 (1997): 375-379. https://doi.org/10.3892/ijo.10.2.375