Differential regulation of glucose transporter-1 and -2 gene expression by hepatocyte growth factor in human hepatoblastoma cells

  • Authors:
    • T Ueki
    • K Nakata
    • F Mawatari
    • H Yamasaki
    • S Tsuruta
    • A Ido
    • K Nakao
    • Y Kato
    • S Nagataki
  • View Affiliations

  • Published online on: February 1, 1997     https://doi.org/10.3892/ijo.10.2.363
  • Pages: 363-366
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Abstract

Glucose transporters, GLUT-1 and GLUT-2, are key factors involved in facilitative glucose transport to hepatocytes. The aim of the present study was to clarify how hepatocyte growth factor (HGF) regulates expression of both genes in HepG2 human hepatoblastoma cells. HGF dose-dependently suppressed cell growth, but enhanced cellular glucose uptake together with increased expression of GLUT-1 protein. This increase resulted from elevation of its transcript. In contrast, no changes were found in expression of GLUT-2 protein or its transcript by HGF treatment. These results indicate that HGF stimulates glucose incorporation through the selective up-regulation of GLUT-1 gene expression in HepG2 cells.

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February 1997
Volume 10 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Ueki, T., Nakata, K., Mawatari, F., Yamasaki, H., Tsuruta, S., Ido, A. ... Nagataki, S. (1997). Differential regulation of glucose transporter-1 and -2 gene expression by hepatocyte growth factor in human hepatoblastoma cells. International Journal of Oncology, 10, 363-366. https://doi.org/10.3892/ijo.10.2.363
MLA
Ueki, T., Nakata, K., Mawatari, F., Yamasaki, H., Tsuruta, S., Ido, A., Nakao, K., Kato, Y., Nagataki, S."Differential regulation of glucose transporter-1 and -2 gene expression by hepatocyte growth factor in human hepatoblastoma cells". International Journal of Oncology 10.2 (1997): 363-366.
Chicago
Ueki, T., Nakata, K., Mawatari, F., Yamasaki, H., Tsuruta, S., Ido, A., Nakao, K., Kato, Y., Nagataki, S."Differential regulation of glucose transporter-1 and -2 gene expression by hepatocyte growth factor in human hepatoblastoma cells". International Journal of Oncology 10, no. 2 (1997): 363-366. https://doi.org/10.3892/ijo.10.2.363