BRCA1-p53 relationship in hereditary breast cancer

  • Authors:
    • H Sobol
    • D StoppaLyonnet
    • B BressacDePaillerets
    • J Peyrat
    • J Guinebretiere
    • J Jacquemier
    • F Eisinger
    • D Birnbaum
  • View Affiliations

  • Published online on: February 1, 1997     https://doi.org/10.3892/ijo.10.2.349
  • Pages: 349-353
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Abstract

BRCA1, a major gene predisposing to breast and ovarian cancers, encodes a ring finger-containing protein. Its function is still unknown. Recently, the existence of a new structural domain called BRCT was postulated. This domain has some similarity with the 53BP1 human protein involved in p53 binding process. To test for a possible relationship between BRCA1 and p53, we compared p53 expression by immunohistochemical analysis in 29 BRCA1-associated breast cancers from 19 families, and in 200 consecutive sporadic breast cancers. We observed a prevalence of tumors with p53 positive staining in the BRCA1 population (p=0.003). In addition, p53 expression was affected by the site of the germ line mutation in the BRCA1 gene. p53 staining was found more consistently in tumors associated with mutations that lead to a truncation of BRCA1 in the ring finger region (p=0.0048). These results favor the hypothesis of a cooperation between BRCA1 and p53. Further experiments are needed to explore the full bilogical relevance of this phenomenon.

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February 1997
Volume 10 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Sobol, H., StoppaLyonnet, D., BressacDePaillerets, B., Peyrat, J., Guinebretiere, J., Jacquemier, J. ... Birnbaum, D. (1997). BRCA1-p53 relationship in hereditary breast cancer. International Journal of Oncology, 10, 349-353. https://doi.org/10.3892/ijo.10.2.349
MLA
Sobol, H., StoppaLyonnet, D., BressacDePaillerets, B., Peyrat, J., Guinebretiere, J., Jacquemier, J., Eisinger, F., Birnbaum, D."BRCA1-p53 relationship in hereditary breast cancer". International Journal of Oncology 10.2 (1997): 349-353.
Chicago
Sobol, H., StoppaLyonnet, D., BressacDePaillerets, B., Peyrat, J., Guinebretiere, J., Jacquemier, J., Eisinger, F., Birnbaum, D."BRCA1-p53 relationship in hereditary breast cancer". International Journal of Oncology 10, no. 2 (1997): 349-353. https://doi.org/10.3892/ijo.10.2.349