Clinical and ethical issues in the diagnosis of hereditary breast cancer (review)

  • Authors:
    • R Ponzone
    • M Giai
    • R Roagna
    • L Sgro
    • N Biglia
    • H Welch
    • P Sismondi
  • View Affiliations

  • Published online on: February 1, 1997     https://doi.org/10.3892/ijo.10.2.323
  • Pages: 323-328
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

A small subset of breast and ovarian cancers is related to the mutation of dominant susceptibility genes. The recent isolation of BRCA1 and BRCA2 has created great interest and expectations among members of families with a positive history for breast/ovarian cancer. We reviewed the literature to explore the clinical implications of genetic testing for BRCA1 and BRCA2 mutations among high risk women. Both the value of the information provided by the test and the efficacy of the preventive and diagnostic measures presently available have been examined. We also specifically address the issue of ethical dilemmas arising from widespread availability of genetic information, including psycological reactions of those who receive the test, genetic discrimination by health insurance companies or employers and prenatal testing for BRCA1 mutations.

Related Articles

Journal Cover

February 1997
Volume 10 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Ponzone, R., Giai, M., Roagna, R., Sgro, L., Biglia, N., Welch, H., & Sismondi, P. (1997). Clinical and ethical issues in the diagnosis of hereditary breast cancer (review). International Journal of Oncology, 10, 323-328. https://doi.org/10.3892/ijo.10.2.323
MLA
Ponzone, R., Giai, M., Roagna, R., Sgro, L., Biglia, N., Welch, H., Sismondi, P."Clinical and ethical issues in the diagnosis of hereditary breast cancer (review)". International Journal of Oncology 10.2 (1997): 323-328.
Chicago
Ponzone, R., Giai, M., Roagna, R., Sgro, L., Biglia, N., Welch, H., Sismondi, P."Clinical and ethical issues in the diagnosis of hereditary breast cancer (review)". International Journal of Oncology 10, no. 2 (1997): 323-328. https://doi.org/10.3892/ijo.10.2.323