ras and myc analysis in primary and metastatic colorectal carcinomas

  • Authors:
    • I Albanese
    • C Rinaudo
    • M Alberti
    • V Bazan
    • A Russo
    • M Migliavacca
    • P Bazan
    • G Dardanoni
    • R Tomasino
    • M LaFarina
  • View Affiliations

  • Published online on: February 1, 1997     https://doi.org/10.3892/ijo.10.2.293
  • Pages: 293-300
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Abstract

Paired primary colorectal adenocarcinoma and normal frozen tissue samples from 60 patients were prospectively studied to determine the frequency of point mutations in K-ras and the occurrence of structural alterations in c-myc. Parallel investigations were performed on liver metastatic specimens from 16 of the patients. 47% of the primary tumors presented point mutations in K-ras; 71% of these were in codon 12. Significant associations were found between codon 13 ras mutations and Dukes' D stage (p<0.05), and between mutations in codon 12 and mucinous type (p<0.01). The c-myc gene structure was altered in 5/60 cases (8%). In 4/16 cases, the K-ras gene status in the primary carcinoma and in the metastatic tissue from the same patient was found to be different. Our results suggest that codon 13 I-as mutations may be associated with an increased invasive and metastatic potential, while codon 12 mutations may have a role in the mucinous differentiation pathway.

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February 1997
Volume 10 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Albanese, I., Rinaudo, C., Alberti, M., Bazan, V., Russo, A., Migliavacca, M. ... LaFarina, M. (1997). ras and myc analysis in primary and metastatic colorectal carcinomas. International Journal of Oncology, 10, 293-300. https://doi.org/10.3892/ijo.10.2.293
MLA
Albanese, I., Rinaudo, C., Alberti, M., Bazan, V., Russo, A., Migliavacca, M., Bazan, P., Dardanoni, G., Tomasino, R., LaFarina, M."ras and myc analysis in primary and metastatic colorectal carcinomas". International Journal of Oncology 10.2 (1997): 293-300.
Chicago
Albanese, I., Rinaudo, C., Alberti, M., Bazan, V., Russo, A., Migliavacca, M., Bazan, P., Dardanoni, G., Tomasino, R., LaFarina, M."ras and myc analysis in primary and metastatic colorectal carcinomas". International Journal of Oncology 10, no. 2 (1997): 293-300. https://doi.org/10.3892/ijo.10.2.293