Influence of 1 alpha,25-dihydroxyvitamin D-3 on growth regulation through epidermal growth factor receptor in human breast cancer cell lines

  • Authors:
    • T Takeo
    • Y Iino
    • H Aoyagi
    • Y Horii
    • F Ikeda
  • View Affiliations

  • Published online on: February 1, 1997     https://doi.org/10.3892/ijo.10.2.287
  • Pages: 287-291
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Abstract

We investigated the relationship between epidermal growth factor (EGF) dependent cell growth and antiproliferative effects of 1 alpha,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3) in hormone responsive breast cancer cell lines in vitro. MCF-7 breast cancer cells and GMC-M, which is a serum-independent, hormone receptor-positive subtype derived from MCF-7, were used in this study. EGF stimulated the growth Of both cell lines, and 1,25(OH)(2)D-3 inhibited the EGF-stimulated cell growth in a dose dependent fashion. But treatment with 1,25(OH)(2)D-3 did not change the EGF receptor (EGFR) level significantly in either cell line. GMC-M had a higher level of EGFR and was more sensitive to EGF than MCF-7. These results suggest that other mechanisms of action, which are different from EGFR modulation, concern with the growth inhibitory effect of 1,25(OH)(2)D-3, and that 1,25(OH)(2)D-3 will be a new effective treatment for breast cancer irrespective of EGFR.

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February 1997
Volume 10 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Takeo, T., Iino, Y., Aoyagi, H., Horii, Y., & Ikeda, F. (1997). Influence of 1 alpha,25-dihydroxyvitamin D-3 on growth regulation through epidermal growth factor receptor in human breast cancer cell lines. International Journal of Oncology, 10, 287-291. https://doi.org/10.3892/ijo.10.2.287
MLA
Takeo, T., Iino, Y., Aoyagi, H., Horii, Y., Ikeda, F."Influence of 1 alpha,25-dihydroxyvitamin D-3 on growth regulation through epidermal growth factor receptor in human breast cancer cell lines". International Journal of Oncology 10.2 (1997): 287-291.
Chicago
Takeo, T., Iino, Y., Aoyagi, H., Horii, Y., Ikeda, F."Influence of 1 alpha,25-dihydroxyvitamin D-3 on growth regulation through epidermal growth factor receptor in human breast cancer cell lines". International Journal of Oncology 10, no. 2 (1997): 287-291. https://doi.org/10.3892/ijo.10.2.287