Loss of heterozygosity and microsatellite instability in larynx cancer
- J Louhelainen
- K Szyfter
- W Szyfter
- K Hemminki
Affiliations: POLISH ACAD SCI,INST HUMAN GENET,PL-60479 POZNAN,POLAND. POZNAN TECH UNIV,DEPT OTOLARYNGOL,SCH MED,PL-60355 POZNAN,POLAND.
- Published online on: February 1, 1997 https://doi.org/10.3892/ijo.10.2.247
Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
We have examined 48 squamous cell cancers of the larynx for loss of heterozygosity (LOH) and microsatellite instability at chromosome 9p near the p16 tumour suppressor locus, at chromosome 17p at the p53 tumour suppressor locus, and at 17p at another microsatellite locus (D17S520). In p53 LOH was higher (33-45%) than in D17S520 (21%). Near the p16 locus LOH varied from 28-38%. Replication errors were found from at least one locus in 23% of the patients. These data suggest that p53 is an important gene in laryngeal cancer while loci around p16 appear less likely candidates.