Loss of heterozygosity and microsatellite instability in larynx cancer

  • Authors:
    • J Louhelainen
    • K Szyfter
    • W Szyfter
    • K Hemminki
  • View Affiliations

  • Published online on: February 1, 1997     https://doi.org/10.3892/ijo.10.2.247
  • Pages: 247-252
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Abstract

We have examined 48 squamous cell cancers of the larynx for loss of heterozygosity (LOH) and microsatellite instability at chromosome 9p near the p16 tumour suppressor locus, at chromosome 17p at the p53 tumour suppressor locus, and at 17p at another microsatellite locus (D17S520). In p53 LOH was higher (33-45%) than in D17S520 (21%). Near the p16 locus LOH varied from 28-38%. Replication errors were found from at least one locus in 23% of the patients. These data suggest that p53 is an important gene in laryngeal cancer while loci around p16 appear less likely candidates.

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February 1997
Volume 10 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Louhelainen, J., Szyfter, K., Szyfter, W., & Hemminki, K. (1997). Loss of heterozygosity and microsatellite instability in larynx cancer. International Journal of Oncology, 10, 247-252. https://doi.org/10.3892/ijo.10.2.247
MLA
Louhelainen, J., Szyfter, K., Szyfter, W., Hemminki, K."Loss of heterozygosity and microsatellite instability in larynx cancer". International Journal of Oncology 10.2 (1997): 247-252.
Chicago
Louhelainen, J., Szyfter, K., Szyfter, W., Hemminki, K."Loss of heterozygosity and microsatellite instability in larynx cancer". International Journal of Oncology 10, no. 2 (1997): 247-252. https://doi.org/10.3892/ijo.10.2.247