MITOCHONDRIA AS A TARGET FOR COMBINATION CANCER-CHEMOTHERAPY

  • Authors:
    • G SINGH
    • R MOOREHEAD
  • View Affiliations

  • Published online on: December 1, 1992     https://doi.org/10.3892/ijo.1.7.825
  • Pages: 825-829
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Abstract

The purpose of this study was to examine whether mitochondria could be used as a potential target for combination cancer chemotherapy. Mitochondrial specific agents, namely Dequalinium chloride and Rhodamine 123 were tested as single agent and in combination with cis-diammine dichloroplatinum (II). Combination of either cis-diammine dichloroplatinum (II) and Rhodamine 123 or cis-diammine dichloroplatinum (II) and Dequalinium chloride showed that there was a synergistic action. However, combination of Rhodamine 123 and Dequalinium chloride showed a slight antagonistic activity which could be due to competition for the same site. The data also show that a much lower dose of cisplatin is required to produce an equieffective-response when used in combination with Dequalinium chloride and thus may lower the cis-diammine dichloroplatinum (II) induced toxicities.

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December 1992
Volume 1 Issue 7

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
SINGH, G., & SINGH, G. (1992). MITOCHONDRIA AS A TARGET FOR COMBINATION CANCER-CHEMOTHERAPY. International Journal of Oncology, 1, 825-829. https://doi.org/10.3892/ijo.1.7.825
MLA
SINGH, G., MOOREHEAD, R."MITOCHONDRIA AS A TARGET FOR COMBINATION CANCER-CHEMOTHERAPY". International Journal of Oncology 1.7 (1992): 825-829.
Chicago
SINGH, G., MOOREHEAD, R."MITOCHONDRIA AS A TARGET FOR COMBINATION CANCER-CHEMOTHERAPY". International Journal of Oncology 1, no. 7 (1992): 825-829. https://doi.org/10.3892/ijo.1.7.825