IMMUNOHISTOCHEMICAL EVALUATION OF MAM-3 AND MAM-6 ANTIGENS IN SQUAMOUS-CELL CARCINOMA OF THE ORAL CAVITY
- M KUNIKATA
- K YAMADA
- K OGATA
- M MORI
- Y TATEMOTO
- T OSAKI
- A TUBURA
- S MORII
Affiliations: ASAHI UNIV,SCH DENT,DEPT ORAL & MAXILLOFACIAL SURG,1851-1 HOZUMI CHO,MOTOSU,GIFU 50102,JAPAN. KANSAI MED UNIV,DEPT PATHOL,MORIGUCHI,OSAKA 570,JAPAN. KOCHI MED SCH,DEPT ORAL SURG,NANKOKU,KOCHI 78151,JAPAN.
- Published online on: December 1, 1992 https://doi.org/10.3892/ijo.1.7.753
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MAM-3 and MAM-6 antigens of human milk fat globule membrane designated as human polymorphic epithelial mucin (PEM) were detected immunohistochemically in a total of 86 specimens from 39 cases of oral squamous cell carcinoma (SCC) and 6 cases of normal oral mucosa. The two antigens were identified by MoAbs 67D11 and 115G3 (MAM-3 antigen) and by MoAbs 115D8 and 115F5 (MAM-6 antigen) in paraffin sections. MoAb 115G3 staining was found in well keratinized foci; whereas, MoAb 115D8 and 115F5 staining was very low in keratinized tumor cells. The cytochemical distribution of the antigens was classified into 3 types; (i) cell membrane positive type, (ii) whole cell positive type and (iii) antigen negative type. Reduction and disappearance of the two antigens were correlated to the mode of tumor invasion and suggested that glycocalyx complex in cell membrane properties was changed for malignant transformation.