CYTOGENETIC AND MOLECULAR ANALYSIS OF SYNOVIAL SARCOMA

  • Authors:
    • JC KNIGHT
    • BR REEVES
    • S SMITH
    • J CLARK
    • C FISHER
    • CDM FLETCHER
    • BA GUSTERSON
    • CS COOPER
  • View Affiliations

  • Published online on: December 1, 1992     https://doi.org/10.3892/ijo.1.7.747
  • Pages: 747-752
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

We have carried out cytogenetic studies on a series of ten synovial sarcomas. Five of these tumours contained the characteristic reciprocal translocation t(X;18) (p11.2;q11.2) and a further two tumours contained complex rearrangements involving chromosomes X and 18. Secondary clonal alterations were seen in four tumours. Candidate genes at Xp11.2-p11.3 have been assessed for involvement in the translocation by Northern and Southern analysis: genes encoding transcription factors (ELK1 and TFE3), a metalloproteinase inhibitor (TIMP-1), a ubiquitin-activating enzyme (UBE1), a serine-threonine kinase (ARAF1) and the neural cell phosphoprotein synapsin 1 (SYN1). We found no evidence of abnormal transcription or rearrangements of these genes in a panel of synovial sarcoma biopsies and cell lines, indicating that they are not directly involved in the t(X;18) chromosome translocation.

Related Articles

Journal Cover

December 1992
Volume 1 Issue 7

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
KNIGHT, J., REEVES, B., SMITH, S., CLARK, J., FISHER, C., FLETCHER, C. ... COOPER, C. (1992). CYTOGENETIC AND MOLECULAR ANALYSIS OF SYNOVIAL SARCOMA. International Journal of Oncology, 1, 747-752. https://doi.org/10.3892/ijo.1.7.747
MLA
KNIGHT, J., REEVES, B., SMITH, S., CLARK, J., FISHER, C., FLETCHER, C., GUSTERSON, B., COOPER, C."CYTOGENETIC AND MOLECULAR ANALYSIS OF SYNOVIAL SARCOMA". International Journal of Oncology 1.7 (1992): 747-752.
Chicago
KNIGHT, J., REEVES, B., SMITH, S., CLARK, J., FISHER, C., FLETCHER, C., GUSTERSON, B., COOPER, C."CYTOGENETIC AND MOLECULAR ANALYSIS OF SYNOVIAL SARCOMA". International Journal of Oncology 1, no. 7 (1992): 747-752. https://doi.org/10.3892/ijo.1.7.747