METHYLATION OF CHROMOSOME 11P GENES IN WILMS-TUMOR AND KIDNEY TISSUE
- JC WILLIAMS
- NJ MAITLAND
- MG MOTT
- KW BROWN
Affiliations: UNIV WALK,SCH MED SCI,DEPT PATHOL & MICROBIOL,CANC & LEUKAEMIA CHILDHOOD TRUST LAB,BRISTOL BS8 1TD,ENGLAND.
- Published online on: December 1, 1992 https://doi.org/10.3892/ijo.1.7.743
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Three genes on the short arm of chromosome 11 (WT1, IGF2 and HRAS) were hypomethylated in Wilms' tumour tissue compared to normal kidney tissue, and one (CALCA) was hypermethylated. IGF2 and HRAS showed evidence of allele-specific methylation, which may indicate genomic imprinting of the 11p15 region in some kidney cells.