Open Access

Circular RNA_101237 mediates anoxia/reoxygenation injury by targeting let‑7a‑5p/IGF2BP3 in cardiomyocytes

  • Authors:
    • Jianting Gan
    • Jun Yuan
    • Yu Liu
    • Zhengde Lu
    • Yan Xue
    • Lei Shi
    • Huayuan Zeng
  • View Affiliations

  • Published online on: December 23, 2019     https://doi.org/10.3892/ijmm.2019.4441
  • Pages: 451-460
  • Copyright: © Gan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Circular RNAs (circRNAs) serve important roles in cardiovascular diseases, including myocardial infarction. However, the mechanisms underlying the roles of circRNAs in cardiomyocyte death induced by anoxia/reoxygenation (A/R) are not fully understood. In the present study, the roles of circRNA_101237 and let‑7a‑5p in cardiomyocyte death induced by A/R injury were investigated. It was identified that circRNA_101237 was induced by A/R injury in a time‑dependent manner and that circRNA_101237 knockdown protected cardiomyocytes from A/R‑mediated apoptosis. Additional mechanistic studies revealed that circRNA_101237 served as a sponge for let‑7a‑5p, subsequently regulating insulin‑like growth factor 2 mRNA‑binding protein 3 (IGF2BP3)‑dependent autophagy. IGF2BP3 downregulation decreased the levels of apoptosis and inhibited autophagy induced by A/R challenge in primary cardiomyocytes. These results identified circRNA_101237 as a novel circRNA that regulates cardiomyocyte death and autophagy, and demonstrated that the circRNA‑101237/let‑7a‑5p/IGF2BP3 axis, which serves as a regulator of cardiomyocyte death, may be a potential therapeutic target for the management of cardiovascular diseases.
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February 2020
Volume 45 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Gan, J., Yuan, J., Liu, Y., Lu, Z., Xue, Y., Shi, L., & Zeng, H. (2020). Circular RNA_101237 mediates anoxia/reoxygenation injury by targeting let‑7a‑5p/IGF2BP3 in cardiomyocytes. International Journal of Molecular Medicine, 45, 451-460. https://doi.org/10.3892/ijmm.2019.4441
MLA
Gan, J., Yuan, J., Liu, Y., Lu, Z., Xue, Y., Shi, L., Zeng, H."Circular RNA_101237 mediates anoxia/reoxygenation injury by targeting let‑7a‑5p/IGF2BP3 in cardiomyocytes". International Journal of Molecular Medicine 45.2 (2020): 451-460.
Chicago
Gan, J., Yuan, J., Liu, Y., Lu, Z., Xue, Y., Shi, L., Zeng, H."Circular RNA_101237 mediates anoxia/reoxygenation injury by targeting let‑7a‑5p/IGF2BP3 in cardiomyocytes". International Journal of Molecular Medicine 45, no. 2 (2020): 451-460. https://doi.org/10.3892/ijmm.2019.4441