Open Access

The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)

  • Authors:
    • Fatima Ardito
    • Michele Giuliani
    • Donatella Perrone
    • Giuseppe Troiano
    • Lorenzo Lo Muzio
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  • Published online on: June 22, 2017     https://doi.org/10.3892/ijmm.2017.3036
  • Pages: 271-280
  • Copyright: © Ardito et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Protein phosphorylation is an impo­rtant cellular regulatory mechanism as many enzymes and receptors are activated/deactivated by phosphorylation and dephosphorylation events, by means of kinases and phosph­atases. In particular, the protein kinases are responsible for cellular transduction signaling and their hyperactivity, malfunction or overexpression can be found in several diseases, mostly tumors. Therefore, it is evident that the use of kinase inhibitors can be valuable for the treatment of cancer. In this review, we discuss the mechanism of action of phosphorylation, with particular attention to the importance of phosphorylation under physiological and pathological conditions. We also discuss the possibility of using kinase inhibitors in the treatment of tumors.
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August 2017
Volume 40 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Ardito, F., Giuliani, M., Perrone, D., Troiano, G., & Lo Muzio, L. (2017). The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review). International Journal of Molecular Medicine, 40, 271-280. https://doi.org/10.3892/ijmm.2017.3036
MLA
Ardito, F., Giuliani, M., Perrone, D., Troiano, G., Lo Muzio, L."The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)". International Journal of Molecular Medicine 40.2 (2017): 271-280.
Chicago
Ardito, F., Giuliani, M., Perrone, D., Troiano, G., Lo Muzio, L."The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)". International Journal of Molecular Medicine 40, no. 2 (2017): 271-280. https://doi.org/10.3892/ijmm.2017.3036