Senescence of mesenchymal stem cells (Review)

  • Authors:
    • Yi Li
    • Qiong Wu
    • Yujia Wang
    • Li Li
    • Hong Bu
    • Ji Bao
  • View Affiliations

  • Published online on: March 9, 2017     https://doi.org/10.3892/ijmm.2017.2912
  • Pages: 775-782
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Mesenchymal stem cells (MSCs) have been used in cell-based therapy for various diseases, due to their immunomodulatory and inflammatory effects. However, the function of MSCs is known to decline with age, a process that is called senescence. To date, the process of MSC senescence remains unknown as in-depth understanding of the mechanisms involved in cellular senescence is lacking. First, senescent MSCs are so heterogeneous that not all of them express the same phenotypic markers. In addition, the genes and signaling pathways which regulate this process in MSCs are still unknown. Thus, an understanding of the molecular processes controlling MSC senescence is crucial to determining the drivers and effectors of age-associated MSC dysfunction. Moreover, the proper use of MSCs for clinical application requires a general understanding of the MSC aging process. Furthermore, such knowledge is essential for the development of therapeutic interventions that can slow or reverse age-related degenerative changes to enhance repair processes and maintain healthy function in aging tissues. To further clarify the properties of senescent cells, as well as to present significant findings from studies on the mechanisms of cellular aging, we summarize these biological features in the senescence of MSCs in this scenario. This review summarizes recent advances in our understanding of the markers and differentiation potential indicating MSC senescence, as well as factors affecting MSC senescence with particular emphasis on the roles of oxidative stress, intrinsic changes in telomere shortening, histone deacetylase and DNA methyltransferase, genes and signaling pathways and immunological properties.
View Figures
View References

Related Articles

Journal Cover

April 2017
Volume 39 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Li, Y., Wu, Q., Wang, Y., Li, L., Bu, H., & Bao, J. (2017). Senescence of mesenchymal stem cells (Review). International Journal of Molecular Medicine, 39, 775-782. https://doi.org/10.3892/ijmm.2017.2912
MLA
Li, Y., Wu, Q., Wang, Y., Li, L., Bu, H., Bao, J."Senescence of mesenchymal stem cells (Review)". International Journal of Molecular Medicine 39.4 (2017): 775-782.
Chicago
Li, Y., Wu, Q., Wang, Y., Li, L., Bu, H., Bao, J."Senescence of mesenchymal stem cells (Review)". International Journal of Molecular Medicine 39, no. 4 (2017): 775-782. https://doi.org/10.3892/ijmm.2017.2912