Anticancer effects of ginsenoside Rg3 (Review)

  • Authors:
    • Mengyao Sun
    • Ying Ye
    • Ling Xiao
    • Xinya Duan
    • Yongming Zhang
    • Hong Zhang
  • View Affiliations

  • Published online on: January 13, 2017     https://doi.org/10.3892/ijmm.2017.2857
  • Pages: 507-518
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Abstract

Cancer is a life-threatening disease with an alarmingly increased annual mortality rate globally. Although various therapies are employed for cancer, the final effect is not satisfactory. Chemotherapy is currently the most commonly used treatment option. However, the unsatisfactory efficacy, severe side-effects and drug resistance hinder the therapeutic efficacy of chemotherapeutic drugs. There is increasing evidence indicating that ginsenoside Rg3, a naturally occurring phytochemical, plays an important role in the prevention and treatment of cancer. The suggested mechanisms mainly include the induction of apoptosis, and the inhibition of proliferation, metastasis and angiogenesis, as well as the promotion of immunity. In addition, ginsenoside Rg3 can be used as an adjuvant to conventional cancer therapies, improving the efficacy and/or reducing adverse effects via synergistic activities. Ginsenoside Rg3 may be a widely applied natural medicine against cancer. To date however, there is no systematic summary available of the anticancer effects of ginsenoside Rg3. Therefore, in this review, all available literature over the past 10 years was reviewed and discussed in order to facilitate further research of ginsenoside Rg3.
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March 2017
Volume 39 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Sun, M., Ye, Y., Xiao, L., Duan, X., Zhang, Y., & Zhang, H. (2017). Anticancer effects of ginsenoside Rg3 (Review). International Journal of Molecular Medicine, 39, 507-518. https://doi.org/10.3892/ijmm.2017.2857
MLA
Sun, M., Ye, Y., Xiao, L., Duan, X., Zhang, Y., Zhang, H."Anticancer effects of ginsenoside Rg3 (Review)". International Journal of Molecular Medicine 39.3 (2017): 507-518.
Chicago
Sun, M., Ye, Y., Xiao, L., Duan, X., Zhang, Y., Zhang, H."Anticancer effects of ginsenoside Rg3 (Review)". International Journal of Molecular Medicine 39, no. 3 (2017): 507-518. https://doi.org/10.3892/ijmm.2017.2857